PDE2A

PDE2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Identifiers
Aliases	PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A, IDDPADS
External IDs	OMIM: 602658; MGI: 2446107; HomoloGene: 1952; GeneCards: PDE2A; OMA:PDE2A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,674,591 bp
RNA expression pattern
	Top expressed in
	spleen; ; right frontal lobe; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; nucleus accumbens;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; calcium channel activity; cGMP binding; metal ion binding; cyclic-nucleotide phosphodiesterase activity; protein binding; phosphoric diester hydrolase activity; TPR domain binding; hydrolase activity; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cAMP binding; protein homodimerization activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; identical protein binding; magnesium ion binding; zinc ion binding; phosphate ion binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; plasma membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; presynaptic membrane; nucleus; mitochondrial outer membrane; mitochondrial inner membrane; mitochondrial matrix;
Biological process	establishment of endothelial barrier; cellular response to transforming growth factor beta stimulus; positive regulation of inflammatory response; cellular response to cGMP; negative regulation of transcription by RNA polymerase II; monocyte differentiation; cGMP-mediated signaling; cellular response to macrophage colony-stimulating factor stimulus; cellular response to mechanical stimulus; positive regulation of vascular permeability; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cAMP-mediated signaling; signal transduction; negative regulation of vascular permeability; cGMP catabolic process; cAMP catabolic process; calcium ion transmembrane transport; G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling; cellular response to cAMP; cellular response to 2,3,7,8-tetrachlorodibenzodioxine; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of gene expression; negative regulation of cGMP-mediated signaling; regulation of mitochondrion organization; heart valve development; ventricular septum development; aorta development;
	Sources:Amigo / QuickGO
Orthologs
	5138
	207728
	ENSG00000186642
	ENSMUSG00000030653
	O00408
	Q922S4
	NM_001143839; NM_001146209; NM_001243784; NM_002599
	NM_001008548; NM_001143848; NM_001143849; NM_001243757; NM_001243758
	NP_001137311; NP_001139681; NP_001230713; NP_002590
	NP_001008548; NP_001137320; NP_001137321; NP_001230686; NP_001230687
	Wikidata
View/Edit Human	View/Edit Mouse

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[4]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186642 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
^ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186642 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9210593-4] Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.

[entrez-5] "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

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