PDE4A

PDE4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QYK, 3I8V, 3TVX
Identifiers
Aliases	PDE4A, DPDE2, PDE4, PDE46, phosphodiesterase 4A
External IDs	OMIM: 600126; MGI: 99558; HomoloGene: 4520; GeneCards: PDE4A; OMA:PDE4A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,469,630 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,124,544 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; lateral nuclear group of thalamus; ; parietal lobe; ; postcentral gyrus; ; primary visual cortex; ; superior frontal gyrus; ; right frontal lobe; ; muscle of thigh; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; muscle of thigh; ; seminiferous tubule; ; cerebellar cortex; ; right ventricle; ; olfactory epithelium; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; cAMP binding; protein binding; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; 3',5'-cyclic-AMP phosphodiesterase activity;
Cellular component	cytoplasm; ruffle membrane; perinuclear region of cytoplasm; cytosol; cell projection; membrane; nucleoplasm; plasma membrane;
Biological process	sensory perception of smell; regulation of cAMP-mediated signaling; cAMP catabolic process; regulation of protein kinase A signaling; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5141
	18577
	ENSG00000065989
	ENSMUSG00000032177
	P27815
	O89084
	NM_001111307; NM_001111308; NM_001111309; NM_001243121; NM_006202
	NM_019798; NM_183408; NM_001310750
	NP_001104777; NP_001104778; NP_001104779; NP_001230050; NP_006193
	NP_001297679; NP_062772; NP_899668
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065989 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032177 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somatic Cell and Molecular Genetics. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. S2CID 19182571.
^ "PDE4A phosphodiesterase 4A, cAMP-specific ( Homo sapiens )". Entrez Gene. 2012-03-04. Retrieved 2012-04-02.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065989 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032177 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8009369-5] Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somatic Cell and Molecular Genetics. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. S2CID 19182571.

[entrez-6] "PDE4A phosphodiesterase 4A, cAMP-specific ( Homo sapiens )". Entrez Gene. 2012-03-04. Retrieved 2012-04-02.

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