PDE4C

PDE4C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QYM
Identifiers
Aliases	PDE4C, DPDE1, phosphodiesterase 4C, PDE21
External IDs	OMIM: 600128; MGI: 99556; HomoloGene: 20256; GeneCards: PDE4C; OMA:PDE4C - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,248,200 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,203,835 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; tibial arteries; ; spleen; ; skeletal muscle tissue; ; gastrocnemius muscle; ; left ventricle; ; testicle; ; muscle layer of sigmoid colon; ; stromal cell of endometrium;
	Top expressed in
	renal cortex; ; proximal tubule; ; human kidney; ; right kidney; ; islet of Langerhans; ; hepatobiliary system; ; liver; ; muscle of thigh; ; muscle tissue; ; duodenum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; protein binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; 3',5'-cyclic-AMP phosphodiesterase activity;
Cellular component	cytosol; cell projection; extracellular space; cilium;
Biological process	cAMP catabolic process; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5143
	110385
	ENSG00000105650
	ENSMUSG00000031842
	Q08493
	Q3UEI1
NM_000923; NM_001098818; NM_001098819; NM_001330172; NM_001369701;
	NM_001395274
	NM_201607; NM_001310465
	NP_000914; NP_001092288; NP_001092289; NP_001317101; NP_001356630
	NP_001297394; NP_963901
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105650 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031842 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105650 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031842 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".

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