PDE4D

PDE4D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU
Identifiers
Aliases	PDE4D, ACRDYS2, DPDE3, HSPDE43, PDE4DN2, STRK1, phosphodiesterase 4D
External IDs	OMIM: 600129; MGI: 99555; HomoloGene: 129755; GeneCards: PDE4D; OMA:PDE4D - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	60,522,120 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	110,089,995 bp
RNA expression pattern
	Top expressed in
	glutes; ; muscle of arm; ; biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; Achilles tendon; ; gastrocnemius muscle; ; vastus lateralis muscle;
	Top expressed in
	muscle of thigh; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; olfactory bulb; ; Cortex of frontal lobe; ; right kidney; ; proximal tubule; ; superior frontal gyrus; ; primary visual cortex; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ATPase binding; scaffold protein binding; cAMP binding; metal ion binding; beta-2 adrenergic receptor binding; protein binding; phosphoric diester hydrolase activity; enzyme binding; hydrolase activity; ubiquitin protein ligase binding; transmembrane transporter binding; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity;
Cellular component	cytoplasm; cytosol; centrosome; microtubule organizing center; apical plasma membrane; cytoskeleton; membrane; calcium channel complex; voltage-gated calcium channel complex; plasma membrane; nuclear membrane;
Biological process	establishment of endothelial barrier; smooth muscle contraction; positive regulation of interleukin-5 production; multicellular organism growth; human ageing; regulation of signaling receptor activity; positive regulation of interferon-gamma production; neutrophil chemotaxis; positive regulation of interleukin-2 production; regulation of cell communication by electrical coupling involved in cardiac conduction; adrenergic receptor signaling pathway; cellular response to lipopolysaccharide; T cell receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate; cAMP-mediated signaling; cellular response to cAMP; signal transduction; leukocyte migration; negative regulation of relaxation of cardiac muscle; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; negative regulation of heart contraction; regulation of heart rate; regulation of ryanodine-sensitive calcium-release channel activity; cAMP catabolic process; cellular response to epinephrine stimulus; regulation of cardiac muscle cell contraction; negative regulation of peptidyl-serine phosphorylation; G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5144
	238871
	ENSG00000113448
	ENSMUSG00000021699
	Q08499
	Q01063
NM_001104631; NM_001165899; NM_001197218; NM_001197219; NM_001197220;
	NM_001197221; NM_001197222; NM_001197223; NM_006203; NM_001349241; NM_001349242; NM_001349243; NM_001364599; NM_001364600; NM_001364601; NM_001364602; NM_001364603; NM_001364604
	NM_011056; NM_177252
NP_001098101; NP_001159371; NP_001184147; NP_001184148; NP_001184149;
	NP_001184150; NP_001184151; NP_001184152; NP_006194; NP_001336170; NP_001336171; NP_001336172; NP_001351528; NP_001351529; NP_001351530; NP_001351531; NP_001351532; NP_001351533
NP_035186; NP_001389812; NP_001389813; NP_001389814; NP_001389815;
	NP_001389816; NP_001389817
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113448 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113448 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021699 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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