PDE6G

PDE6G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JWR
Identifiers
Aliases	PDE6G, PDEG, RP57, phosphodiesterase 6G
External IDs	OMIM: 180073; MGI: 97526; HomoloGene: 1955; GeneCards: PDE6G; OMA:PDE6G - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,663,112 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,344,326 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; granulocyte; ; lymph node; ; spleen; ; retinal pigment epithelium; ; monocyte; ; secondary oocyte; ; blood; ; bone marrow cells;
	Top expressed in
	neural layer of retina; ; epithelium of lens; ; pineal gland; ; retinal pigment epithelium; ; corneal stroma; ; gastrula; ; iris; ; outer nuclear layer; ; right ventricle; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; spectrin binding; cGMP binding; protein binding; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity;
Cellular component	plasma membrane; photoreceptor disc membrane; photoreceptor outer segment membrane;
Biological process	positive regulation of G protein-coupled receptor signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; visual perception; response to stimulus; regulation of rhodopsin mediated signaling pathway; negative regulation of catalytic activity; Wnt signaling pathway, calcium modulating pathway; rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5148
	18588
	ENSG00000185527
	ENSMUSG00000025386
	P18545
	P09174
	NM_002602; NM_001365724; NM_001365725
	NM_012065
	NP_002593; NP_001352653; NP_001352654
	NP_036197
	Wikidata
View/Edit Human	View/Edit Mouse

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185527 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025386 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (February 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
^ "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
^ Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L (February 2019). "Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 5 (2): eaav4322. Bibcode:2019SciA....5.4322G. doi:10.1126/sciadv.aav4322. PMC 6392808. PMID 30820458.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185527 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025386 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2155175-5] Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (February 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.

[entrez-6] "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".

[7] Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L (February 2019). "Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 5 (2): eaav4322. Bibcode:2019SciA....5.4322G. doi:10.1126/sciadv.aav4322. PMC 6392808. PMID 30820458.

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