PDE7A

PDE7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZKL, 3G3N, 4PM0, 4Y2B
Identifiers
Aliases	PDE7A, HCP1, PDE7, phosphodiesterase 7A
External IDs	OMIM: 171885; MGI: 1202402; HomoloGene: 1956; GeneCards: PDE7A; OMA:PDE7A - orthologs
EC number	3.1.4.53
Gene location (Human)
Chr.	Chromosome 8 (human)
End	65,842,322 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	19,365,486 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; thymus; ; Skeletal muscle tissue of rectus abdominis; ; apex of heart; ; muscle of thigh; ; lymph node; ; gastrocnemius muscle; ; deltoid muscle; ; appendix; ; right auricle;
	Top expressed in
	left lung lobe; ; spermatocyte; ; Rostral migratory stream; ; conjunctival fornix; ; left colon; ; ganglionic eminence; ; primitive streak; ; spermatid; ; muscle of thigh; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity;
Cellular component	cytosol; cytoplasm;
Biological process	cAMP catabolic process; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5150
	18583
	ENSG00000205268
	ENSMUSG00000069094
	Q13946
	P70453
	NM_001242318; NM_002603; NM_002604
	NM_001122759; NM_008802
	NP_001229247; NP_002594
	NP_001116231; NP_032828
	Wikidata
View/Edit Human	View/Edit Mouse

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.^[5]^[6]^[7] Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205268 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. doi:10.1016/S0021-9258(18)31474-1. PMID 8389765.
^ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
^ "Entrez Gene: PDE7A phosphodiesterase 7A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205268 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8389765-5] Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. doi:10.1016/S0021-9258(18)31474-1. PMID 8389765.

[pmid9521885-6] Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.

[entrez-7] "Entrez Gene: PDE7A phosphodiesterase 7A".

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