PER2

PER2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GDI, 4CT0, 4U8H
Identifiers
Aliases	PER2, FASPS, FASPS1, period circadian clock 2, period circadian regulator 2
External IDs	OMIM: 603426; MGI: 1195265; HomoloGene: 7885; GeneCards: PER2; OMA:PER2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,290,102 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,387,046 bp
RNA expression pattern
	Top expressed in
	oocyte; ; mucosa of paranasal sinus; ; secondary oocyte; ; bronchial epithelial cell; ; palpebral conjunctiva; ; nasal epithelium; ; tail of epididymis; ; urethra; ; caput epididymis; ; skin of thigh;
	Top expressed in
	adrenal gland; ; left lung lobe; ; suprachiasmatic nucleus; ; granulocyte; ; rectum; ; lacrimal gland; ; median eminence; ; primary motor cortex; ; lobe of cerebellum; ; respiratory epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; transcription cis-regulatory region binding; protein binding; transcription corepressor binding; transcription factor binding;
Cellular component	nucleolus; perinuclear region of cytoplasm; nucleus; cytoplasm;
Biological process	histone H3 deacetylation; gluconeogenesis; regulation of transcription, DNA-templated; regulation of insulin secretion; rhythmic process; negative regulation of fat cell proliferation; negative regulation of circadian rhythm; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; fatty acid metabolic process; regulation of cell cycle; negative regulation of protein ubiquitination; circadian regulation of translation; response to ischemia; regulation of vasoconstriction; glycogen biosynthetic process; negative regulation of transcription regulatory region DNA binding; regulation of circadian rhythm; circadian rhythm; white fat cell differentiation; regulation of glutamate uptake involved in transmission of nerve impulse; lactate biosynthetic process; negative regulation of transcription, DNA-templated; regulation of neurogenesis; positive regulation of nucleic acid-templated transcription; response to light stimulus; entrainment of circadian clock by photoperiod; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8864
	18627
	ENSG00000132326
	ENSMUSG00000055866
	O15055
	O54943
	NM_003894; NM_022817
	NM_011066
	NP_073728
	NP_035196
	Wikidata
View/Edit Human	View/Edit Mouse

PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132326 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055866 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM (Dec 1997). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron. 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249. S2CID 10059149.
^ Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ (Jan 2007). "Modeling of a human circadian mutation yields insights into clock regulation by PER2". Cell. 128 (1): 59–70. doi:10.1016/j.cell.2006.11.043. PMC 1828903. PMID 17218255.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132326 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055866 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9427249-5] Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM (Dec 1997). "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei". Neuron. 19 (6): 1261–9. doi:10.1016/S0896-6273(00)80417-1. PMID 9427249. S2CID 10059149.

[pmid17218255-6] Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ (Jan 2007). "Modeling of a human circadian mutation yields insights into clock regulation by PER2". Cell. 128 (1): 59–70. doi:10.1016/j.cell.2006.11.043. PMC 1828903. PMID 17218255.

[1]

[2]

[3]

[4]

[5]

[6]