PIEZO1

PIEZO1
Identifiers
Aliases	PIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM6
External IDs	OMIM: 611184; MGI: 3603204; HomoloGene: 124356; GeneCards: PIEZO1; OMA:PIEZO1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	88,785,220 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,278,068 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; upper lobe of left lung; ; granulocyte; ; spleen; ; subcutaneous adipose tissue; ; right lung; ; prostate; ; gastric mucosa; ; skin of leg; ; left uterine tube;
	Top expressed in
	endothelial cell of lymphatic vessel; ; vestibular membrane of cochlear duct; ; internal carotid artery; ; external carotid artery; ; stroma of bone marrow; ; otic vesicle; ; iris; ; ciliary body; ; medullary collecting duct; ; calvaria;
	More reference expression data
	n/a
Gene ontology
Molecular function	cation channel activity; mechanosensitive ion channel activity;
Cellular component	integral component of membrane; cell projection; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum membrane; endoplasmic reticulum; lamellipodium membrane; membrane; plasma membrane;
Biological process	ion transmembrane transport; positive regulation of cell-cell adhesion mediated by integrin; cation transport; positive regulation of integrin activation; ion transport; cation transmembrane transport; regulation of membrane potential; detection of mechanical stimulus; cellular response to mechanical stimulus; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9780
	234839
	ENSG00000103335
	ENSMUSG00000014444
	Q92508
	E2JF22
	NM_001142864
	NM_001037298; NM_001357349
	NP_001136336
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

PIEZO1 is a mechanosensitive ion channel protein that in humans is encoded by the gene PIEZO1. PIEZO1 and its close homolog PIEZO2 were cloned in 2010, using an siRNA-based screen for mechanosensitive ion channels.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014444 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels". Science. 330 (6000): 55–60. Bibcode:2010Sci...330...55C. doi:10.1126/science.1193270. PMC 3062430. PMID 20813920.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014444 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[PMID20813920-5] Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels". Science. 330 (6000): 55–60. Bibcode:2010Sci...330...55C. doi:10.1126/science.1193270. PMC 3062430. PMID 20813920.

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