PIP4K2A

PIP4K2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YBX
Identifiers
Aliases	PIP4K2A, PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
External IDs	OMIM: 603140; MGI: 1298206; HomoloGene: 37995; GeneCards: PIP4K2A; OMA:PIP4K2A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	22,714,578 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	19,002,937 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; corpus callosum; ; pars reticulata; ; C1 segment; ; dorsal motor nucleus of vagus nerve; ; subthalamic nucleus; ; Region I of hippocampus proper;
	Top expressed in
	deep cerebellar nuclei; ; anterior horn of spinal cord; ; blood; ; facial motor nucleus; ; pontine nuclei; ; thymus; ; substantia nigra; ; globus pallidus; ; spleen; ; medial vestibular nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; kinase activity; phosphatidylinositol phosphate kinase activity; ATP binding; 1-phosphatidylinositol-3-phosphate 4-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; autophagosome; nucleus; nucleoplasm;
Biological process	megakaryocyte development; phosphatidylinositol metabolic process; positive regulation of autophagosome assembly; phosphorylation; regulation of autophagy; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; regulation of phosphatidylinositol 3-kinase signaling; phospholipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5305
	18718
	ENSG00000150867
	ENSMUSG00000026737
	P48426
	O70172
	NM_005028; NM_001330062
	NM_008845; NM_001355146; NM_001355147; NM_001355148; NM_001355149
	NP_001316991; NP_005019
	NP_032871; NP_001342075; NP_001342076; NP_001342077; NP_001342078
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha is an enzyme that in humans is encoded by the PIP4K2A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026737 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Boronenkov IV, Anderson RA (February 1995). "The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases". The Journal of Biological Chemistry. 270 (7): 2881–2884. doi:10.1074/jbc.270.7.2881. PMID 7852364.
^ Rameh LE, Tolias KF, Duckworth BC, Cantley LC (November 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–196. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID 9367159. S2CID 4403301.
^ "Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150867 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026737 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7852364-5] Boronenkov IV, Anderson RA (February 1995). "The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases". The Journal of Biological Chemistry. 270 (7): 2881–2884. doi:10.1074/jbc.270.7.2881. PMID 7852364.

[pmid9367159-6] Rameh LE, Tolias KF, Duckworth BC, Cantley LC (November 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–196. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID 9367159. S2CID 4403301.

[entrez-7] "Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha".

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