PKD2L1

PKD2L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TE3, 4GIF
Identifiers
Aliases	PKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDs	OMIM: 604532; MGI: 1352448; HomoloGene: 22946; GeneCards: PKD2L1; OMA:PKD2L1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,330,264 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,180,881 bp
RNA expression pattern
	Top expressed in
	spleen; ; right frontal lobe; ; Brodmann area 9; ; sperm; ; glomerulus; ; right lung; ; anterior cingulate cortex; ; prefrontal cortex; ; placenta; ; mononuclear cell;
	Top expressed in
	lumbar subsegment of spinal cord; ; spermatocyte; ; seminiferous tubule; ; embryo; ; embryo; ; anterior horn of spinal cord; ; tongue; ; vallate papilla; ; gastrula; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium activated cation channel activity; muscle alpha-actinin binding; calcium channel activity; cation transmembrane transporter activity; calcium-activated potassium channel activity; sodium channel activity; cytoskeletal protein binding; protein binding; alpha-actinin binding; cation channel activity; identical protein binding; sour taste receptor activity;
Cellular component	integral component of membrane; cell projection; calcium channel complex; membrane; intracellular membrane-bounded organelle; receptor complex; plasma membrane; cilium; cell surface; endoplasmic reticulum; ciliary membrane; cation channel complex; non-motile cilium; integral component of plasma membrane; cytoplasmic vesicle;
Biological process	sodium ion transmembrane transport; cellular response to acidic pH; cation transport; sensory perception of sour taste; ion transport; protein homotrimerization; calcium ion transmembrane transport; detection of mechanical stimulus; potassium ion transmembrane transport; smoothened signaling pathway; detection of chemical stimulus involved in sensory perception of sour taste; calcium ion transport; response to water; detection of chemical stimulus involved in sensory perception of taste; protein tetramerization; protein homotetramerization; cellular response to pH; inorganic cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9033
	329064
	ENSG00000107593
	ENSMUSG00000037578
	Q9P0L9
	A2A259
	NM_001253837; NM_016112
	NM_181422
	NP_001240766; NP_057196
	NP_852087
	Wikidata
View/Edit Human	View/Edit Mouse

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 2 (TRPP2; formerly TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107593 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037578 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107593 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037578 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1".

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