PKM2

PKM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T5A, 1ZJH, 3BJF, 3BJT, 3G2G, 3GQY, 3GR4, 3H6O, 3ME3, 3SRD, 3SRF, 3SRH, 3U2Z, 4B2D, 4FXF, 4FXJ, 4G1N, 4JPG, 4QG6, 4QG8, 4QG9, 4QGC, 4RPP, 4WJ8, 4YJ5
Identifiers
Aliases	PKM, CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, pyruvate kinase, muscle, pyruvate kinase M1/2, p58
External IDs	OMIM: 179050; MGI: 97591; HomoloGene: 37650; GeneCards: PKM; OMA:PKM - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 72,199,029 bp[1] End 72,231,819 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 B|9 32.03 cM Start 59,656,368 bp[2] End 59,679,375 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe prefrontal cortex muscle of thigh Skeletal muscle tissue of rectus abdominis islet of Langerhans right adrenal cortex gastrocnemius muscle left adrenal gland stromal cell of endometrium Top expressed in neural layer of retina dentate gyrus of hippocampal formation granule cell muscle of thigh epiblast granulocyte triceps brachii muscle primary visual cortex superior frontal gyrus skeletal muscle tissue cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding potassium ion binding metal ion binding kinase activity catalytic activity protein binding MHC class II protein complex binding ATP binding magnesium ion binding pyruvate kinase activity RNA binding cadherin binding identical protein binding ADP binding thyroid hormone binding Cellular component cytoplasm extracellular vesicle vesicle extracellular matrix myelin sheath cilium mitochondrion extracellular exosome nucleus extracellular region cytosol secretory granule lumen ficolin-1-rich granule lumen pyruvate kinase complex collagen-containing extracellular matrix Biological process glycolytic process programmed cell death phosphorylation canonical glycolysis metabolism cellular response to insulin stimulus neutrophil degranulation response to hypoxia liver development glucose metabolic process ATP biosynthetic process response to nutrient response to gravity response to organic substance response to muscle inactivity animal organ regeneration response to insulin pyruvate biosynthetic process skeletal muscle tissue regeneration protein homotetramerization positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5315 18746 Ensembl ENSG00000067225 ENSMUSG00000032294 UniProt P14618 P52480 RefSeq (mRNA) NM_001206796 NM_001206797 NM_001206798 NM_001206799 NM_002654 NM_182470 NM_182471 NM_001316318 NM_001253883 NM_011099 RefSeq (protein) NP_001193725 NP_001193726 NP_001193727 NP_001193728 NP_001303247 NP_002645 NP_872270 NP_872271 NP_001240812 NP_035229 NP_001365795 NP_001365796 NP_001365797 NP_001365798 NP_001365799 NP_001365800 NP_001365801 NP_001392420 Location (UCSC) Chr 15: 72.2 – 72.23 Mb Chr 9: 59.66 – 59.68 Mb PubMed search [3] [4]
Wikidata
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Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.^[5][6][7][8]

PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.^{[9][10][11][12][13][14][15]}