PLA2G10

PLA2G10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LE6, 1LE7, 4UY1
Identifiers
Aliases	PLA2G10, GXPLA2, GXSPLA2, SPLA2, sPLA2-X, phospholipase A2 group X
External IDs	OMIM: 603603; MGI: 1347522; HomoloGene: 2636; GeneCards: PLA2G10; OMA:PLA2G10 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	14,694,308 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	13,548,847 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; olfactory zone of nasal mucosa; ; testicle; ; duodenum; ; right uterine tube; ; right lung; ; body of stomach; ; body of pancreas; ; upper lobe of left lung;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; left colon; ; pyloric antrum; ; spermatid; ; seminiferous tubule; ; Ileal epithelium; ; embryo; ; morula; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phospholipase A2 activity; phospholipase activity; metal ion binding; hydrolase activity; phospholipid binding; calcium-dependent phospholipase A2 activity;
Cellular component	extracellular region; extracellular space;
Biological process	phosphatidic acid biosynthetic process; positive regulation of protein metabolic process; phosphatidylserine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lysophospholipid transport; lipid metabolism; positive regulation of lipid storage; phosphatidylinositol acyl-chain remodeling; negative regulation of DNA-binding transcription factor activity; axon guidance; lipid catabolic process; positive regulation of prostaglandin secretion; positive regulation of macrophage derived foam cell differentiation; positive regulation of arachidonic acid secretion; phosphatidylglycerol acyl-chain remodeling; negative regulation of cholesterol efflux; cholesterol homeostasis; arachidonic acid metabolic process; phosphatidylcholine acyl-chain remodeling; regulation of macrophage activation; phospholipid metabolic process; arachidonic acid secretion; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	8399
	26565
	ENSG00000276870; ENSG00000069764
	ENSMUSG00000022683
	O15496
	Q9QXX3
	NM_003561
	NM_001291009; NM_011987
	NP_003552
	NP_001277938; NP_036117
	Wikidata
View/Edit Human	View/Edit Mouse

Group 10 secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G10 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000069764 GRCh38: Ensembl release 89: ENSG00000276870, ENSG00000069764 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022683 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cupillard L, Koumanov K, Mattei MG, Lazdunski M, Lambeau G (Jul 1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2". J Biol Chem. 272 (25): 15745–52. doi:10.1074/jbc.272.25.15745. PMID 9188469.
^ "Entrez Gene: PLA2G10 phospholipase A2, group X".

[refGRCh38Ensembl-1] ENSG00000069764 GRCh38: Ensembl release 89: ENSG00000276870, ENSG00000069764 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022683 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9188469-5] Cupillard L, Koumanov K, Mattei MG, Lazdunski M, Lambeau G (Jul 1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2". J Biol Chem. 272 (25): 15745–52. doi:10.1074/jbc.272.25.15745. PMID 9188469.

[entrez-6] "Entrez Gene: PLA2G10 phospholipase A2, group X".

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