PLA2G1B

PLA2G1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ELO
Identifiers
Aliases	PLA2G1B, PLA2, PLA2A, PPLA2, phospholipase A2 group IB
External IDs	OMIM: 172410; MGI: 101842; HomoloGene: 715; GeneCards: PLA2G1B; OMA:PLA2G1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,327,779 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,612,781 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; beta cell; ; lower lobe of lung; ; sperm; ; testicle; ; upper lobe of lung; ; right lung; ; upper lobe of left lung; ; left ovary;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; mucous cell of stomach; ; islet of Langerhans; ; embryo; ; duodenum; ; embryo; ; esophagus; ; right lung; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium-dependent phospholipase A2 activity; metal ion binding; bile acid binding; signaling receptor binding; hydrolase activity; phospholipase A2 activity; phospholipid binding;
Cellular component	secretory granule; extracellular region; cell surface; extracellular space; cytosol;
Biological process	phosphatidic acid biosynthetic process; phosphatidylserine acyl-chain remodeling; intracellular signal transduction; phosphatidylethanolamine acyl-chain remodeling; positive regulation of calcium ion transport into cytosol; lipid metabolism; actin filament organization; interleukin-8 production; phosphatidylinositol acyl-chain remodeling; activation of phospholipase A2 activity; neutrophil chemotaxis; fatty acid biosynthetic process; positive regulation of immune response; innate immune response in mucosa; positive regulation of NF-kappaB transcription factor activity; phosphatidylglycerol acyl-chain remodeling; positive regulation of protein secretion; cellular response to insulin stimulus; neutrophil mediated immunity; leukotriene biosynthetic process; phosphatidylcholine metabolic process; phosphatidylcholine acyl-chain remodeling; positive regulation of transcription by RNA polymerase II; signal transduction; phospholipid metabolic process; arachidonic acid secretion; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of glucose import; positive regulation of cell population proliferation; lipid catabolic process; positive regulation of fibroblast proliferation; antibacterial humoral response; defense response to Gram-positive bacterium;
	Sources:Amigo / QuickGO
Orthologs
	5319
	18778
	ENSG00000170890
	ENSMUSG00000029522
	P04054
	Q9Z0Y2
	NM_000928
	NM_011107; NM_001356586; NM_001356587
	NP_000919
	NP_035237; NP_001343515; NP_001343516
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase A₂, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170890 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029522 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". J Biol Chem. 269 (18): 13057–60. doi:10.1016/S0021-9258(17)36794-7. PMID 8175726.
^ "Entrez Gene: PLA2G1B phospholipase A2, group IB (pancreas)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170890 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029522 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8175726-5] Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". J Biol Chem. 269 (18): 13057–60. doi:10.1016/S0021-9258(17)36794-7. PMID 8175726.

[entrez-6] "Entrez Gene: PLA2G1B phospholipase A2, group IB (pancreas)".

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