PLA2G4A

PLA2G4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BCI, 1CJY, 1RLW
Identifiers
Aliases	PLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
External IDs	OMIM: 600522; MGI: 1195256; HomoloGene: 32059; GeneCards: PLA2G4A; OMA:PLA2G4A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	186,988,981 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	149,837,041 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; cartilage tissue; ; right uterine tube; ; urinary bladder; ; caput epididymis; ; mucosa of urinary bladder; ; germinal epithelium; ; Achilles tendon; ; parietal pleura; ; jejunal mucosa;
	Top expressed in
	epithelium of lens; ; mucous cell of stomach; ; urothelium; ; cervix; ; epithelium of stomach; ; transitional epithelium of urinary bladder; ; Paneth cell; ; cumulus cell; ; gastrula; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; hydrolase activity; calcium-dependent phospholipid binding; phospholipase activity; phospholipase A2 activity; phospholipase A1 activity; lysophospholipase activity; calcium-dependent phospholipase A2 activity;
Cellular component	Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane; cytoplasmic vesicle; mitochondrial inner membrane; cytoplasm; lipid droplet; cytosol; nucleus;
Biological process	phospholipid metabolic process; phosphatidylinositol acyl-chain remodeling; platelet activating factor biosynthetic process; arachidonic acid secretion; icosanoid metabolic process; lipid metabolism; phosphatidylserine acyl-chain remodeling; phospholipid catabolic process; phosphatidylglycerol acyl-chain remodeling; cellular response to antibiotic; lipid catabolic process; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; metabolism; regulation of cell population proliferation; phosphatidylethanolamine acyl-chain remodeling; cardiolipin acyl-chain remodeling; icosanoid biosynthetic process; arachidonic acid metabolic process; glycerophospholipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5321
	18783
	ENSG00000116711
	ENSMUSG00000056220
	P47712
	P47713
	NM_001311193; NM_024420
	NM_008869; NM_001305632
	NP_001298122; NP_077734
	NP_001292561; NP_032895
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G4A gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116711 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". Journal of Biological Chemistry. 269 (18): 13057–13060. doi:10.1016/S0021-9258(17)36794-7. PMID 8175726.
^ "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116711 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056220 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8175726-5] Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". Journal of Biological Chemistry. 269 (18): 13057–13060. doi:10.1016/S0021-9258(17)36794-7. PMID 8175726.

[entrez-6] "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)".

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