PLA2G6

PLA2G6
Identifiers
Aliases	PLA2G6, CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta, phospholipase A2 group VI
External IDs	OMIM: 603604; MGI: 1859152; HomoloGene: 2635; GeneCards: PLA2G6; OMA:PLA2G6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,214,778 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,328,390 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gallbladder; ; right adrenal cortex; ; sural nerve; ; granulocyte; ; right testis; ; left ovary; ; left testis;
	Top expressed in
	gastrula; ; seminiferous tubule; ; spermatid; ; spermatocyte; ; muscle of thigh; ; left lobe of liver; ; transitional epithelium of urinary bladder; ; islet of Langerhans; ; yolk sac; ; brown adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phospholipase A2 activity; ATP-dependent protein binding; calmodulin binding; calcium-independent phospholipase A2 activity; hydrolase activity; serine hydrolase activity; protein kinase binding;
Cellular component	membrane; microtubule organizing center; mitochondrion; extracellular space; cytoplasm; cytosol;
Biological process	positive regulation of ceramide biosynthetic process; positive regulation of protein phosphorylation; phosphatidylethanolamine acyl-chain remodeling; urinary bladder smooth muscle contraction; maternal process involved in female pregnancy; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of store-operated calcium channel activity; positive regulation of protein kinase C signaling; lipid metabolism; positive regulation of cytosolic calcium ion concentration; antibacterial humoral response; memory; response to endoplasmic reticulum stress; chemotaxis; lipid catabolic process; positive regulation of arachidonic acid secretion; cardiolipin biosynthetic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; metabolism; negative regulation of synaptic transmission, glutamatergic; phosphatidylcholine acyl-chain remodeling;
	Sources:Amigo / QuickGO
Orthologs
	8398
	53357
	ENSG00000184381
	ENSMUSG00000042632
	O60733
	P97819
NM_001004426; NM_001199562; NM_003560; NM_001349864; NM_001349865;
	NM_001349866; NM_001349867; NM_001349868; NM_001349869
	NM_001199023; NM_001199024; NM_001199025; NM_016915
NP_001004426; NP_001186491; NP_003551; NP_001336793; NP_001336794;
	NP_001336795; NP_001336796; NP_001336797; NP_001336798
	NP_001185952; NP_001185953; NP_001185954; NP_058611
	Wikidata
View/Edit Human	View/Edit Mouse

85 kDa calcium-independent phospholipase A2, also known as 85/88 kDa calcium-independent phospholipase A2, Group VI phospholipase A2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, or Patatin-like phospholipase domain-containing protein 9 is an enzyme that in humans is encoded by the PLA2G6 gene.^[5]^[6]^[7]^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184381 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042632 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Larsson PK, Claesson HE, Kennedy BP (January 1998). "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity". The Journal of Biological Chemistry. 273 (1): 207–214. doi:10.1074/jbc.273.1.207. PMID 9417066.
^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (September 2006). "Characterization of the human patatin-like phospholipase family". Journal of Lipid Research. 47 (9): 1940–1949. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.
^ Kienesberger PC, Oberer M, Lass A, Zechner R (April 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". Journal of Lipid Research. 50 Suppl (Suppl): S63–S68. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.
^ "Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)". This article incorporates text from this source, which is in the public domain.
^ "PLA2G6 - 85/88 kDa calcium-independent phospholipase A2 - Homo sapiens (Human) - PLA2G6 gene & protein". Retrieved 2018-08-22. This article incorporates text available under the CC BY 4.0 license.
^ "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184381 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042632 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417066-5] Larsson PK, Claesson HE, Kennedy BP (January 1998). "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity". The Journal of Biological Chemistry. 273 (1): 207–214. doi:10.1074/jbc.273.1.207. PMID 9417066.

[pmid16799181-6] Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (September 2006). "Characterization of the human patatin-like phospholipase family". Journal of Lipid Research. 47 (9): 1940–1949. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.

[pmid19029121-7] Kienesberger PC, Oberer M, Lass A, Zechner R (April 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". Journal of Lipid Research. 50 Suppl (Suppl): S63–S68. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.

[entrez-8] "Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)". This article incorporates text from this source, which is in the public domain.

[uniprot-9] "PLA2G6 - 85/88 kDa calcium-independent phospholipase A2 - Homo sapiens (Human) - PLA2G6 gene & protein". Retrieved 2018-08-22. This article incorporates text available under the CC BY 4.0 license.

[uniprot0-10] "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.

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