PLCB2

PLCB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FJU, 2ZKM
Identifiers
Aliases	PLCB2, PLC-beta-2, phospholipase C beta 2
External IDs	OMIM: 604114; MGI: 107465; HomoloGene: 20957; GeneCards: PLCB2; OMA:PLCB2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,307,935 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	118,558,919 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; spleen; ; blood; ; bone marrow cells; ; lymph node; ; appendix; ; upper lobe of left lung; ; right lung; ; C1 segment;
	Top expressed in
	granulocyte; ; thymus; ; female urethra; ; male urethra; ; lumbar subsegment of spinal cord; ; blood; ; spermatocyte; ; spleen; ; ascending aorta; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; phospholipase C activity; calcium ion binding; hydrolase activity; signal transducer activity; metal ion binding; phosphatidylinositol phospholipase C activity;
Cellular component	cytoplasm; cytosol;
Biological process	lipid catabolic process; sensory perception of bitter taste; phospholipid metabolic process; intracellular signal transduction; inositol phosphate metabolic process; activation of phospholipase C activity; signal transduction; lipid metabolism; Wnt signaling pathway, calcium modulating pathway; G protein-coupled receptor signaling pathway; inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	5330
	18796
	ENSG00000137841
	ENSMUSG00000040061
	Q00722
	A3KGF7
	NM_001284297; NM_001284298; NM_001284299; NM_004573
	NM_001290790; NM_177568
	NP_001271226; NP_001271227; NP_001271228; NP_004564
	NP_001277719; NP_808236
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137841 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040061 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2". J. Biol. Chem. 267 (23): 16048–55. doi:10.1016/S0021-9258(18)41963-1. PMID 1644792.
^ Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 48–9. doi:10.1159/000015166. PMID 9925923. S2CID 45169136.
^ "Entrez Gene: PLCB2 phospholipase C, beta 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137841 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040061 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1644792-5] Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2". J. Biol. Chem. 267 (23): 16048–55. doi:10.1016/S0021-9258(18)41963-1. PMID 1644792.

[pmid9925923-6] Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 48–9. doi:10.1159/000015166. PMID 9925923. S2CID 45169136.

[entrez-7] "Entrez Gene: PLCB2 phospholipase C, beta 2".

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