PLCB4

PLCB4
Identifiers
Aliases	PLCB4, ARCND2, PI-PLC, phospholipase C beta 4
External IDs	OMIM: 600810; MGI: 107464; HomoloGene: 8471; GeneCards: PLCB4; OMA:PLCB4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	9,481,242 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	135,856,513 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; lateral nuclear group of thalamus; ; sural nerve; ; bronchial epithelial cell; ; cerebellar cortex; ; cerebellar hemisphere; ; mucosa of sigmoid colon; ; mucosa of paranasal sinus; ; right hemisphere of cerebellum; ; cerebellar vermis;
	Top expressed in
	vestibular membrane of cochlear duct; ; medial geniculate nucleus; ; medial dorsal nucleus; ; parotid gland; ; iris; ; submandibular gland; ; cerebellar vermis; ; lobe of cerebellum; ; lateral geniculate nucleus; ; superior colliculus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phospholipase C activity; phosphoric diester hydrolase activity; calcium ion binding; protein binding; hydrolase activity; signal transducer activity; phosphatidylinositol phospholipase C activity;
Cellular component	cytosol; dendrite; nucleus; postsynaptic density; smooth endoplasmic reticulum; parallel fiber to Purkinje cell synapse; glutamatergic synapse; postsynapse; intracellular anatomical structure;
Biological process	lipid metabolism; lipid catabolic process; signal transduction; intracellular signal transduction; inositol phosphate metabolic process; G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission; inositol trisphosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5332
	18798
	ENSG00000101333
	ENSMUSG00000039943
	Q15147
	n/a
	NM_000933; NM_001172646; NM_182797
	NM_013829; NM_001355153; NM_001355154; NM_001355155; NM_001355156
NP_000924; NP_001166117; NP_877949; NP_001364063; NP_001364064;
	NP_001364065; NP_001364071; NP_001364072
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101333 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039943 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W (Feb 1996). "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)". Genomics. 29 (1): 53–61. doi:10.1006/geno.1995.1214. PMID 8530101.
^ "Entrez Gene: PLCB4 phospholipase C, beta 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101333 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039943 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530101-5] Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W (Feb 1996). "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)". Genomics. 29 (1): 53–61. doi:10.1006/geno.1995.1214. PMID 8530101.

[entrez-6] "Entrez Gene: PLCB4 phospholipase C, beta 4".

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