PLCD4

PLCD4
Identifiers
Aliases	PLCD4, phospholipase C delta 4
External IDs	OMIM: 605939; MGI: 107469; HomoloGene: 88782; GeneCards: PLCD4; OMA:PLCD4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,637,184 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,606,953 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; vastus lateralis muscle; ; gastrocnemius muscle; ; skeletal muscle tissue; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; tibialis anterior muscle; ; gastric mucosa;
	Top expressed in
	medial head of gastrocnemius muscle; ; triceps brachii muscle; ; knee joint; ; vastus lateralis muscle; ; seminiferous tubule; ; spermatid; ; sternocleidomastoid muscle; ; spermatocyte; ; tibialis anterior muscle; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; phospholipase C activity; calcium ion binding; hydrolase activity; signal transducer activity; metal ion binding; phosphatidylinositol phospholipase C activity;
Cellular component	plasma membrane; nuclear membrane; intracellular anatomical structure; endoplasmic reticulum; nucleus; membrane; cytoplasm; endoplasmic reticulum membrane; cytosol;
Biological process	lipid catabolic process; acrosome reaction; intracellular signal transduction; phosphatidylinositol metabolic process; signal transduction; lipid metabolism; inositol phosphate metabolic process; inositol trisphosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	84812
	18802
	ENSG00000115556
	ENSMUSG00000026173
	Q9BRC7
	Q8K3R3
	NM_032726
	NM_001081456; NM_148937
	NP_116115
	NP_001074925; NP_683739
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115556 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026173 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization". Cytogenet Cell Genet. 87 (3–4): 254–5. doi:10.1159/000015437. PMID 10702683. S2CID 40877378.
^ Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
^ "Entrez Gene: PLCD4 phospholipase C, delta 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115556 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026173 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10702683-5] Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization". Cytogenet Cell Genet. 87 (3–4): 254–5. doi:10.1159/000015437. PMID 10702683. S2CID 40877378.

[pmid9056492-6] Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.

[entrez-7] "Entrez Gene: PLCD4 phospholipase C, delta 4".

[1]

[2]

[3]

[4]

[5]

[6]

[7]