PLCG2

PLCG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K2J, 2W2W, 2W2X
Identifiers
Aliases	PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2
External IDs	OMIM: 600220; MGI: 97616; HomoloGene: 55671; GeneCards: PLCG2; OMA:PLCG2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	81,962,685 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	118,361,881 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; bone marrow cells; ; blood; ; metanephric glomerulus; ; epithelium of nasopharynx; ; spleen; ; granulocyte; ; endothelial cell; ; appendix; ; kidney tubule;
	Top expressed in
	basilar part of occipital bone; ; granulocyte; ; tibiofemoral joint; ; mesenteric lymph nodes; ; spleen; ; bone marrow; ; blood; ; sphenoid bone; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; phosphoric diester hydrolase activity; phospholipase C activity; hydrolase activity; phosphatidylinositol phospholipase C activity; phosphotyrosine residue binding;
Cellular component	cytosol; plasma membrane; extracellular exosome;
Biological process	B cell receptor signaling pathway; release of sequestered calcium ion into cytosol; intracellular signal transduction; inositol trisphosphate biosynthetic process; Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of receptor internalization; lipid metabolism; stimulatory C-type lectin receptor signaling pathway; inositol phosphate metabolic process; Wnt signaling pathway; platelet activation; Fc-epsilon receptor signaling pathway; lipid catabolic process; follicular B cell differentiation; response to lipopolysaccharide; phospholipid catabolic process; regulation of gene expression; phosphatidylinositol biosynthetic process; negative regulation of programmed cell death; B cell differentiation; T cell receptor signaling pathway; activation of store-operated calcium channel activity; positive regulation of type I interferon production; calcium-mediated signaling; signal transduction; phosphatidylinositol-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5336
	234779
	ENSG00000197943
	ENSMUSG00000034330
	P16885
	Q8CIH5
	NM_002661
	NM_172285
	NP_002652
	NP_758489
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197943 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). "Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse". Genomics. 23 (2): 504–7. doi:10.1006/geno.1994.1533. PMID 7835906.
^ "Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835906-5] Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). "Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse". Genomics. 23 (2): 504–7. doi:10.1006/geno.1994.1533. PMID 7835906.

[entrez-6] "Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)".

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