PLD2

PLD2
Identifiers
Aliases	PLD2, phospholipase D2, PLD1C
External IDs	OMIM: 602384; MGI: 892877; HomoloGene: 55672; GeneCards: PLD2; OMA:PLD2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,823,434 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,448,936 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; right hemisphere of cerebellum; ; ectocervix; ; right ovary; ; skin of abdomen; ; minor salivary glands; ; left ovary; ; tibial nerve; ; apex of heart; ; ventricular zone;
	Top expressed in
	lip; ; esophagus; ; zygote; ; secondary oocyte; ; ankle; ; primary oocyte; ; vestibular membrane of cochlear duct; ; choroid plexus of fourth ventricle; ; dentate gyrus of hippocampal formation granule cell; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase D activity; N-acylphosphatidylethanolamine-specific phospholipase D activity; protein binding; catalytic activity; phosphatidylinositol binding; hydrolase activity;
Cellular component	Golgi apparatus; endoplasmic reticulum membrane; membrane; plasma membrane; presynapse;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; lipid metabolism; cell motility; small GTPase mediated signal transduction; lipid catabolic process; synaptic vesicle recycling; cytoskeleton organization; phosphatidic acid biosynthetic process; inositol lipid-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5338
	18806
	ENSG00000129219
	ENSMUSG00000020828
	O14939
	P97813
	NM_001243108; NM_002663
	NM_008876; NM_001302475; NM_001302476; NM_001361935
	NP_001230037; NP_002654
	NP_001289404; NP_001289405; NP_032902; NP_001348864
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020828 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Park SH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 225. doi:10.1159/000015106. PMID 9858823. S2CID 46805227.
^ Lopez I, Arnold RS, Lambeth JD (May 1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". The Journal of Biological Chemistry. 273 (21): 12846–52. doi:10.1074/jbc.273.21.12846. PMID 9582313.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020828 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9858823-5] Park SH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 225. doi:10.1159/000015106. PMID 9858823. S2CID 46805227.

[pmid9582313-6] Lopez I, Arnold RS, Lambeth JD (May 1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". The Journal of Biological Chemistry. 273 (21): 12846–52. doi:10.1074/jbc.273.21.12846. PMID 9582313.

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