PLEKHG2

PLEKHG2
Identifiers
AliasesPLEKHG2, ARHGEF42, CLG, LDAMD, pleckstrin homology and RhoGEF domain containing G2, CTB-60E11.4
External IDsOMIM: 611893; MGI: 2141874; HomoloGene: 16341; GeneCards: PLEKHG2; OMA:PLEKHG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022835
NM_001351693
NM_001351694

NM_001083912
NM_001290542
NM_138752

RefSeq (protein)

NP_073746
NP_001338622
NP_001338623

NP_001077381
NP_001277471
NP_620091

Location (UCSC)Chr 19: 39.41 – 39.43 MbChr 7: 28.36 – 28.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain containing, family G member 2 (PLEKHG2) is a protein that in humans is encoded by the PLEKHG2 gene. It is sometimes written as ARHGEF42, FLJ00018.

The PLEKHG2 protein is a huge protein of about 1300 amino acids, 130 kDa and has a Dbl homology (DH) domain and a pleckstrin homology (PH) domain near the N terminus of its structure. The DH domain is a domain responsible for guanine nucleotide exchange activity that converts GDP on the Rho family Small GTPase (RhoGTPase) to GTP, and PLEKHG2 having this domain also acts as a Rho-specific guanine nucleotide exchange factor (RhoGEF).

Activation of RhoGTPase reconstitute the actin cytoskeleton and changes the cell morphology, so PLEKHG2 might be contributes to cell motility and neuronal network development of neurons via RhoGTPase and actin remodeling (see later).

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090924Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037552Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.