PLEKHG2

PLEKHG2
Identifiers
Aliases	PLEKHG2, ARHGEF42, CLG, LDAMD, pleckstrin homology and RhoGEF domain containing G2, CTB-60E11.4
External IDs	OMIM: 611893; MGI: 2141874; HomoloGene: 16341; GeneCards: PLEKHG2; OMA:PLEKHG2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 39,412,669 bp[1] End 39,428,415 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 16.71 cM Start 28,359,604 bp[2] End 28,372,599 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Descending thoracic aorta right coronary artery left uterine tube ascending aorta appendix ganglionic eminence gastric mucosa bone marrow cells stromal cell of endometrium Top expressed in internal carotid artery external carotid artery tail of embryo genital tubercle vas deferens thymus abdominal wall Rostral migratory stream tunica media of zone of aorta ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component cytosol Biological process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction positive regulation of apoptotic process regulation of actin filament polymerization G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64857 101497 Ensembl ENSG00000090924 ENSMUSG00000037552 UniProt Q9H7P9 Q6KAU7 RefSeq (mRNA) NM_022835 NM_001351693 NM_001351694 NM_001083912 NM_001290542 NM_138752 RefSeq (protein) NP_073746 NP_001338622 NP_001338623 NP_001077381 NP_001277471 NP_620091 Location (UCSC) Chr 19: 39.41 – 39.43 Mb Chr 7: 28.36 – 28.37 Mb PubMed search [3] [4]
Wikidata
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Pleckstrin homology domain containing, family G member 2 (PLEKHG2) is a protein that in humans is encoded by the PLEKHG2 gene. It is sometimes written as ARHGEF42, FLJ00018.

The PLEKHG2 protein is a huge protein of about 1300 amino acids, 130 kDa and has a Dbl homology (DH) domain and a pleckstrin homology (PH) domain near the N terminus of its structure. The DH domain is a domain responsible for guanine nucleotide exchange activity that converts GDP on the Rho family Small GTPase (RhoGTPase) to GTP, and PLEKHG2 having this domain also acts as a Rho-specific guanine nucleotide exchange factor (RhoGEF).

Activation of RhoGTPase reconstitute the actin cytoskeleton and changes the cell morphology, so PLEKHG2 might be contributes to cell motility and neuronal network development of neurons via RhoGTPase and actin remodeling (see later).