POLE3

POLE3
Identifiers
Aliases	POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDs	OMIM: 607267; MGI: 1933378; HomoloGene: 9694; GeneCards: POLE3; OMA:POLE3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,410,675 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,443,305 bp
RNA expression pattern
	Top expressed in
	gonad; ; gastrocnemius muscle; ; granulocyte; ; monocyte; ; human penis; ; ganglionic eminence; ; muscle of thigh; ; rectum; ; ventricular zone; ; bone marrow;
	Top expressed in
	spermatocyte; ; ventricular zone; ; yolk sac; ; secondary oocyte; ; zygote; ; fetal liver hematopoietic progenitor cell; ; seminiferous tubule; ; morula; ; molar; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; protein heterodimerization activity; histone acetyltransferase activity;
Cellular component	epsilon DNA polymerase complex; nucleus; nucleoplasm;
Biological process	DNA replication; histone H3 acetylation; DNA biosynthetic process; G1/S transition of mitotic cell cycle; cellular response to DNA damage stimulus; CENP-A containing chromatin assembly; cellular response to gamma radiation; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	54107
	59001
	ENSG00000148229
	ENSMUSG00000028394
	Q9NRF9
	Q9JKP7
	NM_001278255; NM_017443
	NM_021498
	NP_001265184; NP_059139
	NP_067473
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.^[5]^[6]^[7]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
^ Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
^ ^a ^b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10801849-5] Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.

[pmid10880450-6] Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.

[entrez-7] "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]