POLE (gene)

POLE
Identifiers
Aliases	POLE, CRCS12, FILS, POLE1, polymerase (DNA) epsilon, catalytic subunit, DNA polymerase epsilon, catalytic subunit, IMAGEI
External IDs	OMIM: 174762; MGI: 1196391; HomoloGene: 4539; GeneCards: POLE; OMA:POLE - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,687,376 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,485,340 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right testis; ; left testis; ; sural nerve; ; ventricular zone; ; spleen; ; skin of abdomen; ; skin of leg; ; ganglionic eminence; ; right lobe of liver;
	Top expressed in
	otic vesicle; ; otic placode; ; saccule; ; tail of embryo; ; internal carotid artery; ; epiblast; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; ventricular zone; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; DNA binding; 4 iron, 4 sulfur cluster binding; nucleotidyltransferase activity; iron-sulfur cluster binding; zinc ion binding; chromatin binding; metal ion binding; nucleic acid binding; DNA-directed DNA polymerase activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; protein binding;
Cellular component	plasma membrane; nucleoplasm; nucleus; epsilon DNA polymerase complex;
Biological process	nucleotide-excision repair, DNA gap filling; DNA synthesis involved in DNA repair; DNA biosynthetic process; embryonic organ development; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; base-excision repair, gap-filling; DNA repair; DNA replication; leading strand elongation; DNA replication proofreading; G1/S transition of mitotic cell cycle; mitotic cell cycle; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	5426
	18973
	ENSG00000177084
	ENSMUSG00000007080
	Q07864
	Q9WVF7
	NM_006231
	NM_011132
	NP_006222
	NP_035262
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene.^[5]^[6] It is the central catalytic subunit of DNA polymerase epsilon.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177084 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007080 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Szpirer J, Pedeutour F, Kesti T, Riviere M, Syväoja JE, Turc-Carel C, Szpirer C (Aug 1994). "Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization". Genomics. 20 (2): 223–6. doi:10.1006/geno.1994.1156. PMID 8020968.
^ "Entrez Gene: POLE polymerase (DNA directed), epsilon".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177084 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8020968-5] Szpirer J, Pedeutour F, Kesti T, Riviere M, Syväoja JE, Turc-Carel C, Szpirer C (Aug 1994). "Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization". Genomics. 20 (2): 223–6. doi:10.1006/geno.1994.1156. PMID 8020968.

[entrez-6] "Entrez Gene: POLE polymerase (DNA directed), epsilon".

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