Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2gene.[5][6][7]
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID8661009.
^Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene. 213 (1–2): 149–57. doi:10.1016/S0378-1119(98)00193-0. PMID9714608.
