POU4F2

POU4F2
Identifiers
Aliases	POU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDs	OMIM: 113725; MGI: 102524; HomoloGene: 20959; GeneCards: POU4F2; OMA:POU4F2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	146,642,474 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pons; ; pancreatic ductal cell; ; mucosa of ileum; ; sensory ganglion; ; trigeminal ganglion; ; ventral tegmental area; ; medulla oblongata; ; pars compacta; ; superior vestibular nucleus;
	Top expressed in
	lumbar spinal ganglion; ; trigeminal ganglion; ; superior colliculus; ; morula; ; otolith organ; ; inferior colliculi; ; utricle; ; ganglion cell layer; ; embryo; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription coactivator activity; transcription corepressor activity; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding;
Cellular component	nucleoplasm; nucleus; nuclear speck; cytoplasm; plasma membrane; membrane; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; axonogenesis; neuromuscular process controlling balance; hearing; transcription, DNA-templated; MAPK cascade; axon guidance; retina development in camera-type eye; positive regulation of cell differentiation; spermatogenesis; neuron differentiation; axon extension; intracellular estrogen receptor signaling pathway; retinal ganglion cell axon guidance; regulation of signal transduction by p53 class mediator; transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of programmed cell death; negative regulation of cell differentiation; positive regulation of osteoclast differentiation; positive regulation of axon extension; regulation of DNA-binding transcription factor activity; cellular response to cytokine stimulus; cellular response to estradiol stimulus; intrinsic apoptotic signaling pathway by p53 class mediator; regulation of retinal ganglion cell axon guidance; negative regulation of amacrine cell differentiation; dorsal root ganglion development; positive regulation of transcription regulatory region DNA binding; apoptotic process; multicellular organism development; cell differentiation; negative regulation of transcription by RNA polymerase II; heart development; regulation of gene expression; positive regulation of cardiac muscle cell apoptotic process; cellular response to insulin stimulus; positive regulation of glucose import; cellular response to oxygen levels; negative regulation of adipose tissue development;
	Sources:Amigo / QuickGO
Orthologs
	5458
	18997
	ENSG00000151615
	ENSMUSG00000031688
	Q12837
	Q63934
	NM_004575
	NM_138944
	NP_004566
	NP_620394
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.^[4]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151615 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.
^ "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151615 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8332509-4] Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.

[entrez-5] "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".

[1]

[2]

[3]

[4]

[5]