PPP1R15A

PPP1R15A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XPN
Identifiers
Aliases	PPP1R15A, GADD34, protein phosphatase 1 regulatory subunit 15A
External IDs	OMIM: 611048; MGI: 1927072; HomoloGene: 8639; GeneCards: PPP1R15A; OMA:PPP1R15A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,876,058 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,175,692 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; monocyte; ; vena cava; ; sural nerve; ; upper lobe of left lung; ; granulocyte; ; skin of abdomen; ; gallbladder; ; ascending aorta; ; olfactory zone of nasal mucosa;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; decidua; ; granulocyte; ; muscle of thigh; ; islet of Langerhans; ; saccule; ; spleen; ; lip; ; human fetus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; protein phosphatase 1 binding; protein phosphatase activator activity; protein phosphatase regulator activity;
Cellular component	Golgi apparatus; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; protein phosphatase type 1 complex; endoplasmic reticulum; mitochondrion; cytosol; cytoplasm;
Biological process	negative regulation of protein dephosphorylation; cellular response to DNA damage stimulus; positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation; positive regulation of translational initiation in response to stress; positive regulation of phosphoprotein phosphatase activity; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; negative regulation of phosphoprotein phosphatase activity; protein localization to endoplasmic reticulum; regulation of translational initiation by eIF2 alpha dephosphorylation; negative regulation of PERK-mediated unfolded protein response; regulation of translation; apoptotic process; response to endoplasmic reticulum stress; positive regulation of peptidyl-serine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23645
	17872
	ENSG00000087074
	ENSMUSG00000040435
	O75807
	P17564
	NM_014330
	NM_008654
	NP_055145
	NP_032680
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 15A, also known as growth arrest and DNA damage-inducible protein (GADD34), is a protein that in humans is encoded by the PPP1R15A gene.^[5]^[6]^[7]

The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth.^[8] Later on it has been characterized as a gene playing a role in ER stress-induced cell death, being a target of ATF4 that plays a role in ER-mediated cell death via promoting protein dephosphorylation of eIF2α and reversing translational inhibition.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087074 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040435 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hollander MC, Zhan Q, Bae I, Fornace AJ Jr (Jul 1997). "Mammalian GADD34, an apoptosis- and DNA damage-inducible gene". J Biol Chem. 272 (21): 13731–7. doi:10.1074/jbc.272.21.13731. PMID 9153226.
^ Korabiowska M, Betke H, Kellner S, Stachura J, Schauer A (Jan 1998). "Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas". Anticancer Res. 17 (5A): 3697–700. PMID 9413226.
^ "Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A".
^ Zhan Q, Lord KA, Alamo I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace AJ (April 1994). "The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth". Mol. Cell. Biol. 14 (4): 2361–71. doi:10.1128/mcb.14.4.2361. PMC 358603. PMID 8139541.
^ Sano R, Reed JC (July 2013). "ER stress-induced cell death mechanisms". Biochim. Biophys. Acta. 1833 (12): 3460–70. doi:10.1016/j.bbamcr.2013.06.028. PMC 3834229. PMID 23850759.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087074 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9153226-5] Hollander MC, Zhan Q, Bae I, Fornace AJ Jr (Jul 1997). "Mammalian GADD34, an apoptosis- and DNA damage-inducible gene". J Biol Chem. 272 (21): 13731–7. doi:10.1074/jbc.272.21.13731. PMID 9153226.

[pmid9413226-6] Korabiowska M, Betke H, Kellner S, Stachura J, Schauer A (Jan 1998). "Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas". Anticancer Res. 17 (5A): 3697–700. PMID 9413226.

[entrez-7] "Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A".

[pmid8139541-8] Zhan Q, Lord KA, Alamo I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace AJ (April 1994). "The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth". Mol. Cell. Biol. 14 (4): 2361–71. doi:10.1128/mcb.14.4.2361. PMC 358603. PMID 8139541.

[pmid23850759-9] Sano R, Reed JC (July 2013). "ER stress-induced cell death mechanisms". Biochim. Biophys. Acta. 1833 (12): 3460–70. doi:10.1016/j.bbamcr.2013.06.028. PMC 3834229. PMID 23850759.

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