PPP2R2A

PPP2R2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DW8
Identifiers
Aliases	PPP2R2A, B55A, B55ALPHA, PR52A, PR55A, protein phosphatase 2 regulatory subunit Balpha, PR55alpha
External IDs	OMIM: 604941; MGI: 1919228; HomoloGene: 2035; GeneCards: PPP2R2A; OMA:PPP2R2A - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	26,372,680 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	67,309,893 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; mucosa of esophagus; ; oral cavity; ; mucosa of pharynx; ; epithelium of colon; ; ventricular zone; ; glutes; ; secondary oocyte; ; skin of leg; ; skin of abdomen;
	Top expressed in
	tail of embryo; ; somite; ; olfactory tubercle; ; cumulus cell; ; esophagus; ; atrioventricular valve; ; ventricular zone; ; globus pallidus; ; endocardial cushion; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein serine/threonine phosphatase activity; protein phosphatase regulator activity; protein-containing complex binding; tau protein binding; protein phosphatase 2A binding;
Cellular component	nucleoplasm; protein phosphatase type 2A complex; cytosol; synapse; glutamatergic synapse;
Biological process	response to morphine; G2/M transition of mitotic cell cycle; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein dephosphorylation; mitotic cell cycle; peptidyl-serine dephosphorylation; developmental process; regulation of phosphoprotein phosphatase activity; mitotic nuclear membrane reassembly;
	Sources:Amigo / QuickGO
Orthologs
	5520
	71978
	ENSG00000221914
	ENSMUSG00000022052
	P63151
	Q6P1F6
	NM_001177591; NM_002717
	NM_001205188; NM_028032; NM_001360033; NM_001360034
	NP_001171062; NP_002708
	NP_001192117; NP_082308; NP_001346962; NP_001346963
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221914 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022052 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (Apr 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221914 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022052 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1849734-5] Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (Apr 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.

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