PRDX3

PRDX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JCG
Identifiers
Aliases	PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III, peroxiredoxin 3, SCAR32, PPPCD
External IDs	OMIM: 604769; MGI: 88034; HomoloGene: 4944; GeneCards: PRDX3; OMA:PRDX3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11 Start 119,167,720 bp[1] End 119,178,812 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D3|19 56.52 cM Start 60,852,489 bp[2] End 60,862,994 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex right ventricle biceps brachii Skeletal muscle tissue of biceps brachii oocyte islet of Langerhans gastrocnemius muscle secondary oocyte Top expressed in adrenal gland digastric muscle right ventricle temporal muscle right kidney soleus muscle sternocleidomastoid muscle myocardium of ventricle brown adipose tissue triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peroxidase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process kinase binding protein C-terminus binding protein binding antioxidant activity alkyl hydroperoxide reductase activity peroxiredoxin activity oxidoreductase activity protein kinase binding thioredoxin peroxidase activity identical protein binding Cellular component cytosol myelin sheath mitochondrial matrix mitochondrion IkappaB kinase complex cytoplasm endosome early endosome protein-containing complex Biological process myeloid cell differentiation peptidyl-cysteine oxidation mitochondrion organization negative regulation of apoptotic process response to oxidative stress regulation of mitochondrial membrane potential cellular response to reactive oxygen species response to lipopolysaccharide maternal placenta development positive regulation of NF-kappaB transcription factor activity positive regulation of cell population proliferation hydrogen peroxide catabolic process response to hydrogen peroxide negative regulation of kinase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular oxidant detoxification cell redox homeostasis apoptotic process cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10935 11757 Ensembl ENSG00000165672 ENSMUSG00000024997 UniProt P30048 P20108 RefSeq (mRNA) NM_001302272 NM_006793 NM_014098 NM_007452 RefSeq (protein) NP_001289201 NP_006784 NP_031478 Location (UCSC) Chr 10: 119.17 – 119.18 Mb Chr 19: 60.85 – 60.86 Mb PubMed search [3] [4]
Wikidata
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Thioredoxin-dependent peroxide reductase, mitochondrial is an enzyme that in humans is encoded by the PRDX3 gene.^[5][6][7] It is a member of the peroxiredoxin family of antioxidant enzymes.