PRKCI

PRKCI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8
Identifiers
Aliases	PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota
External IDs	OMIM: 600539; MGI: 99260; HomoloGene: 37667; GeneCards: PRKCI; OMA:PRKCI - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	170,305,977 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	31,107,108 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; pylorus; ; lower lobe of lung; ; corpus epididymis; ; cardia; ; oral cavity; ; renal medulla; ; mucosa of pharynx; ; nipple; ; palpebral conjunctiva;
	Top expressed in
	molar; ; ciliary body; ; urothelium; ; hair follicle; ; iris; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; epithelium of lens; ; primitive streak; ; ureter;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein kinase C activity; protein domain specific binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; phospholipid binding; ATP binding;
Cellular component	cytosol; endosome; membrane; bicellular tight junction; microtubule cytoskeleton; Golgi membrane; plasma membrane; apical part of cell; Schmidt-Lanterman incisure; apical plasma membrane; cell leading edge; intercellular bridge; extracellular exosome; nucleus; cytoplasm; nucleoplasm; protein-containing complex; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	negative regulation of neuron apoptotic process; positive regulation of glucose import; establishment of apical/basal cell polarity; intracellular signal transduction; response to interleukin-1; phosphorylation; Golgi vesicle budding; actin filament organization; protein targeting to membrane; negative regulation of glial cell apoptotic process; response to peptide hormone; negative regulation of apoptotic process; secretion; protein phosphorylation; positive regulation of endothelial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; cytoskeleton organization; establishment or maintenance of epithelial cell apical/basal polarity; bicellular tight junction assembly; positive regulation of neuron projection development; cellular response to insulin stimulus; eye photoreceptor cell development; membrane organization; positive regulation of glial cell proliferation; cell migration; vesicle-mediated transport; cell-cell junction organization; peptidyl-serine phosphorylation; positive regulation of protein localization to plasma membrane; positive regulation of Notch signaling pathway; regulation of postsynaptic membrane neurotransmitter receptor levels;
	Sources:Amigo / QuickGO
Orthologs
	5584
	18759
	ENSG00000163558
	ENSMUSG00000037643
	P41743
	Q62074
	NM_002740
	NM_008857
	NP_002731
	NP_032883
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037643 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (Apr 1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics. 26 (3): 629–31. doi:10.1016/0888-7543(95)80190-W. PMID 7607695.
^ De Donato M, Gallagher DS, Davis SK, Stelly DM, Taylor JF (April 2002). "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenetics and Cell Genetics. 95 (1–2): 79–81. doi:10.1159/000057021. PMID 11978974. S2CID 40052490.
^ "Entrez Gene: PRKCI protein kinase C, iota".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037643 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7607695-5] Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (Apr 1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics. 26 (3): 629–31. doi:10.1016/0888-7543(95)80190-W. PMID 7607695.

[pmid11978974-6] De Donato M, Gallagher DS, Davis SK, Stelly DM, Taylor JF (April 2002). "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenetics and Cell Genetics. 95 (1–2): 79–81. doi:10.1159/000057021. PMID 11978974. S2CID 40052490.

[entrez-7] "Entrez Gene: PRKCI protein kinase C, iota".

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