PSMC1

PSMC1
Identifiers
Aliases	PSMC1, P26S4, S4, p56, proteasome 26S subunit, ATPase 1, RPT2
External IDs	OMIM: 602706; MGI: 106054; HomoloGene: 2095; GeneCards: PSMC1; OMA:PSMC1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 90,256,527 bp[1] End 90,275,429 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 E|12 50.43 cM Start 100,076,413 bp[2] End 100,089,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle islet of Langerhans muscle of thigh skeletal muscle tissue placenta smooth muscle tissue left testis endometrium right testis Top expressed in yolk sac neural layer of retina dentate gyrus of hippocampal formation granule cell epiblast lens ventricular zone cerebellum olfactory bulb neural tube skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity protein binding ATP binding hydrolase activity TBP-class protein binding RNA binding proteasome-activating activity Cellular component nuclear proteasome complex proteasome regulatory particle, base subcomplex proteasome regulatory particle cytosolic proteasome complex proteasome accessory complex membrane nucleoplasm nucleus proteasome complex cytoplasm cytosol Biological process positive regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade Fc-epsilon receptor signaling pathway protein catabolic process NIK/NF-kappaB signaling ubiquitin-dependent ERAD pathway anaphase-promoting complex-dependent catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of neuron death Wnt signaling pathway, planar cell polarity pathway positive regulation of proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein folding negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5700 19179 Ensembl ENSG00000100764 ENSMUSG00000021178 UniProt P62191 P62192 RefSeq (mRNA) NM_002802 NM_001330212 NM_008947 RefSeq (protein) NP_001317141 NP_002793 NP_032973 Location (UCSC) Chr 14: 90.26 – 90.28 Mb Chr 12: 100.08 – 100.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

26S protease regulatory subunit 4, also known as 26S proteasome AAA-ATPase subunit Rpt2, is an enzyme that in humans is encoded by the PSMC1 gene.^[5][6] This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex.^[7] Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2 (this protein), Rpt3, Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.^[7]