PSMC2

PSMC2
Identifiers
Aliases	PSMC2, MSS1, Nbla10058, S7, proteasome 26S subunit, ATPase 2, RPT1
External IDs	OMIM: 154365; MGI: 109555; HomoloGene: 2096; GeneCards: PSMC2; OMA:PSMC2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 103,328,570 bp[1] End 103,370,346 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 9.97 cM Start 21,990,281 bp[2] End 22,008,785 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii epithelium of nasopharynx sperm gingival epithelium visceral pleura palpebral conjunctiva skin of hip Skeletal muscle tissue of rectus abdominis parietal pleura tibia Top expressed in facial motor nucleus primitive streak motor neuron superior cervical ganglion medullary collecting duct seminiferous tubule Epithelium of choroid plexus ureter fossa hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity protein binding TBP-class protein binding ATP binding hydrolase activity proteasome-activating activity Cellular component nuclear proteasome complex proteasome regulatory particle, base subcomplex membrane proteasome accessory complex nucleoplasm cytosolic proteasome complex proteasome complex nucleus extracellular region cytoplasm cytosol secretory granule lumen ficolin-1-rich granule lumen P-body cytoplasmic ribonucleoprotein granule dendritic spine Biological process positive regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ubiquitin-dependent protein catabolic process regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade Fc-epsilon receptor signaling pathway protein catabolic process NIK/NF-kappaB signaling osteoblast differentiation ubiquitin-dependent ERAD pathway anaphase-promoting complex-dependent catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process Wnt signaling pathway, planar cell polarity pathway viral process positive regulation of proteasomal protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process neutrophil degranulation transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5701 19181 Ensembl ENSG00000161057 ENSMUSG00000028932 UniProt P35998 P46471 Q8BVQ9 RefSeq (mRNA) NM_001204453 NM_002803 NM_011188 NM_001368661 RefSeq (protein) NP_001191382 NP_002794 NP_035318 NP_001355590 Location (UCSC) Chr 7: 103.33 – 103.37 Mb Chr 5: 21.99 – 22.01 Mb PubMed search [3] [4]
Wikidata
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26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the PSMC2 gene^[5][6][7] This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex.^[8] Six 26S proteasome AAA-ATPase subunits (Rpt1 (this protein), Rpt2, Rpt3, Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.^[8]