PSMC3

PSMC3
Identifiers
Aliases	PSMC3, TBP1, proteasome 26S subunit, ATPase 3, RPT5, DCIDP
External IDs	OMIM: 186852; MGI: 1098754; HomoloGene: 2097; GeneCards: PSMC3; OMA:PSMC3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,418,769 bp[1] End 47,426,473 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E1|2 50.44 cM Start 90,884,354 bp[2] End 90,896,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle muscle of thigh islet of Langerhans ganglionic eminence popliteal artery tibial arteries caudate nucleus Achilles tendon right auricle Top expressed in spermatid spermatocyte seminiferous tubule dentate gyrus of hippocampal formation granule cell endocardial cushion mandibular prominence yolk sac maxillary prominence lens endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity hydrolase activity TBP-class protein binding ATP binding protein binding identical protein binding proteasome-activating activity Cellular component nucleoplasm cytoplasm proteasome regulatory particle, base subcomplex cytosol cytosolic proteasome complex membrane P-body proteasome accessory complex nuclear proteasome complex proteasome complex extracellular region secretory granule lumen ficolin-1-rich granule lumen nucleus Biological process NIK/NF-kappaB signaling MAPK cascade regulation of mRNA stability protein polyubiquitination Fc-epsilon receptor signaling pathway regulation of cellular amino acid metabolic process protein catabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent tumor necrosis factor-mediated signaling pathway blastocyst development stimulatory C-type lectin receptor signaling pathway ubiquitin-dependent ERAD pathway anaphase-promoting complex-dependent catabolic process negative regulation of canonical Wnt signaling pathway positive regulation of RNA polymerase II transcription preinitiation complex assembly T cell receptor signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of proteasomal protein catabolic process viral process Wnt signaling pathway, planar cell polarity pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process neutrophil degranulation transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia modulation by host of viral transcription positive regulation of transcription by RNA polymerase II post-translational protein modification regulation of hematopoietic stem cell differentiation interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5702 19182 Ensembl ENSG00000165916 ENSMUSG00000002102 UniProt P17980 O88685 RefSeq (mRNA) NM_002804 NM_008948 RefSeq (protein) NP_002795 NP_032974 Location (UCSC) Chr 11: 47.42 – 47.43 Mb Chr 2: 90.88 – 90.9 Mb PubMed search [3] [4]
Wikidata
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26S protease regulatory subunit 6A, also known as 26S proteasome AAA-ATPase subunit Rpt5, is an enzyme that in humans is encoded by the PSMC3 gene.^[5][6] This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex^[7] Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4, Rpt5 (this protein), and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.^[7]