PSMC4

PSMC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPSMC4, MIP224, RPT3, S6, TBP-7, TBP7, proteasome 26S subunit, ATPase 4
External IDsOMIM: 602707; MGI: 1346093; HomoloGene: 4744; GeneCards: PSMC4; OMA:PSMC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153001
NM_006503

NM_011874

RefSeq (protein)

NP_006494
NP_694546

NP_036004

Location (UCSC)Chr 19: 39.97 – 39.98 MbChr 7: 27.74 – 27.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3, is an enzyme that in humans is encoded by the PSMC4 gene.[5][6][7] This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex[8] Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3 (this protein), Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.[8]

  1. ^ a b c ENSG00000013275 GRCh38: Ensembl release 89: ENSG00000281221, ENSG00000013275Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030603Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (Mar 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun. 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509.
  6. ^ Choi HS, Seol W, Moore DD (May 1996). "A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily". J Steroid Biochem Mol Biol. 56 (1–6 Spec No): 23–30. doi:10.1016/0960-0760(95)00220-0. PMID 8603043. S2CID 46464350.
  7. ^ Cite error: The named reference entrez was invoked but never defined (see the help page).
  8. ^ a b Gu ZC, Enenkel C (Dec 2014). "Proteasome assembly". Cellular and Molecular Life Sciences. 71 (24): 4729–45. doi:10.1007/s00018-014-1699-8. PMC 11113775. PMID 25107634. S2CID 15661805.