PSMD2

PSMD2
Identifiers
Aliases	PSMD2, P97, RPN1, S2, TRAP2, proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2
External IDs	OMIM: 606223; MGI: 1096584; HomoloGene: 2101; GeneCards: PSMD2; OMA:PSMD2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,299,198 bp[1] End 184,309,050 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 20,470,402 bp[2] End 20,482,164 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell stromal cell of endometrium right testis gastrocnemius muscle left testis muscle of thigh glutes islet of Langerhans right adrenal gland Top expressed in yolk sac muscle of thigh ventricular zone dentate gyrus of hippocampal formation granule cell genital tubercle blastocyst tail of embryo esophagus spermatocyte morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity protein binding endopeptidase activity Cellular component cytosol membrane nucleoplasm proteasome complex extracellular exosome extracellular region proteasome regulatory particle proteasome accessory complex secretory granule lumen ficolin-1-rich granule lumen nucleus proteasome regulatory particle, base subcomplex proteasome storage granule Biological process regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling regulation of protein catabolic process anaphase-promoting complex-dependent catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process neutrophil degranulation transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification proteasome-mediated ubiquitin-dependent protein catabolic process regulation of hematopoietic stem cell differentiation regulation of catalytic activity interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5708 21762 Ensembl ENSG00000175166 ENSMUSG00000006998 UniProt Q13200 Q8VDM4 RefSeq (mRNA) NM_002808 NM_001278708 NM_001278709 NM_134101 RefSeq (protein) NP_001265637 NP_001265638 NP_002799 NP_598862 Location (UCSC) Chr 3: 184.3 – 184.31 Mb Chr 16: 20.47 – 20.48 Mb PubMed search [3] [4]
Wikidata
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26S proteasome non-ATPase regulatory subunit 2, also as known as 26S Proteasome Regulatory Subunit Rpn1 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD2 gene.^[5][6]