PTPN6

PTPN6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ
Identifiers
Aliases	PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, protein tyrosine phosphatase, non-receptor type 6, protein tyrosine phosphatase non-receptor type 6
External IDs	OMIM: 176883; MGI: 96055; HomoloGene: 56589; GeneCards: PTPN6; OMA:PTPN6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,946,468 bp[1] End 6,961,316 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,697,670 bp[2] End 124,715,677 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen monocyte blood bone marrow cells appendix lymph node mucosa of transverse colon right lung upper lobe of left lung Top expressed in granulocyte spleen thymus mesenteric lymph nodes blood tibiofemoral joint stroma of bone marrow gastrula right lung lobe right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity SH3 domain binding phosphatase activity phosphotyrosine residue binding SH2 domain binding protein binding transmembrane receptor protein tyrosine phosphatase activity hydrolase activity protein kinase binding cell adhesion molecule binding protein tyrosine phosphatase activity phosphorylation-dependent protein binding Cellular component cytoplasm cytosol membrane cell-cell junction alpha-beta T cell receptor complex nucleolus extracellular exosome nucleus extracellular region specific granule lumen tertiary granule lumen nucleoplasm protein-containing complex Biological process B cell receptor signaling pathway megakaryocyte development G protein-coupled receptor signaling pathway cell differentiation intracellular signal transduction regulation of release of sequestered calcium ion into cytosol abortive mitotic cell cycle T cell costimulation protein dephosphorylation platelet formation negative regulation of T cell receptor signaling pathway platelet activation negative regulation of humoral immune response mediated by circulating immunoglobulin regulation of G1/S transition of mitotic cell cycle negative regulation of T cell proliferation regulation of type I interferon-mediated signaling pathway negative regulation of peptidyl-tyrosine phosphorylation negative regulation of MAP kinase activity hematopoietic progenitor cell differentiation positive regulation of cell population proliferation negative regulation of MAPK cascade regulation of ERK1 and ERK2 cascade negative regulation of B cell receptor signaling pathway peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of cell adhesion mediated by integrin cell population proliferation platelet aggregation regulation of B cell differentiation leukocyte migration natural killer cell mediated cytotoxicity negative regulation of cell population proliferation dephosphorylation apoptotic process neutrophil degranulation peptidyl-tyrosine dephosphorylation cytokine-mediated signaling pathway negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5777 15170 Ensembl ENSG00000111679 ENSMUSG00000004266 UniProt P29350 P29351 RefSeq (mRNA) NM_002831 NM_080548 NM_080549 NM_001077705 NM_013545 RefSeq (protein) NP_002822 NP_536858 NP_536859 NP_001071173 NP_038573 Location (UCSC) Chr 12: 6.95 – 6.96 Mb Chr 6: 124.7 – 124.72 Mb PubMed search [3] [4]
Wikidata
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Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.^[5]