PTPRA

PTPRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P15, 1YFO
Identifiers
Aliases	PTPRA, HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA, protein tyrosine phosphatase, receptor type A, protein tyrosine phosphatase receptor type A
External IDs	OMIM: 176884; MGI: 97808; HomoloGene: 20621; GeneCards: PTPRA; OMA:PTPRA - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,039,076 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	130,398,044 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ventricular zone; ; ganglionic eminence; ; right frontal lobe; ; prefrontal cortex; ; nucleus accumbens; ; right hemisphere of cerebellum; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; stroma of bone marrow; ; epithelium of lens; ; superior frontal gyrus; ; ventricular zone; ; subiculum; ; right kidney; ; primary visual cortex; ; cerebellar cortex; ; nucleus accumbens;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	receptor complex; integral component of plasma membrane; integral component of membrane; membrane; extracellular exosome; plasma membrane; intracellular anatomical structure; Schaffer collateral - CA1 synapse; integral component of synaptic membrane;
Biological process	dephosphorylation; axon guidance; protein phosphorylation; protein dephosphorylation; MAPK cascade; peptidyl-tyrosine dephosphorylation; insulin receptor signaling pathway; regulation of molecular function; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	5786
	19262
	ENSG00000132670
	ENSMUSG00000027303
	P18433; Q5JWG0
	P18052
	NM_080841; NM_002836; NM_080840
	NM_001163688; NM_008980; NM_001355161
	NP_002827; NP_543030; NP_543031
	NP_001157160; NP_033006; NP_001342090
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132670 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027303 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jirik FR, Janzen NM, Melhado IG, Harder KW (December 1990). "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase". FEBS Lett. 273 (1–2): 239–42. Bibcode:1990FEBSL.273..239J. doi:10.1016/0014-5793(90)81094-5. PMID 2172030. S2CID 31501542.
^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J (October 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc Natl Acad Sci U S A. 87 (18): 7000–4. Bibcode:1990PNAS...87.7000K. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617.
^ "Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132670 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027303 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2172030-5] Jirik FR, Janzen NM, Melhado IG, Harder KW (December 1990). "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase". FEBS Lett. 273 (1–2): 239–42. Bibcode:1990FEBSL.273..239J. doi:10.1016/0014-5793(90)81094-5. PMID 2172030. S2CID 31501542.

[pmid2169617-6] Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J (October 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc Natl Acad Sci U S A. 87 (18): 7000–4. Bibcode:1990PNAS...87.7000K. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617.

[entrez-7] "Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A".

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