PTPRB

PTPRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AHS, 2H02, 2H03, 2H04, 2HC1, 2HC2, 2I3R, 2I3U, 2I4E, 2I4G, 2I4H, 2I5X
Identifiers
Aliases	PTPRB, HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP, protein tyrosine phosphatase, receptor type B, protein tyrosine phosphatase receptor type B
External IDs	OMIM: 176882; MGI: 97809; HomoloGene: 2125; GeneCards: PTPRB; OMA:PTPRB - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	70,637,440 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	116,389,535 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; lower lobe of lung; ; visceral pleura; ; right lung; ; right ventricle; ; parietal pleura; ; upper lobe of lung; ; upper lobe of left lung; ; epithelium of colon; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; external carotid artery; ; internal carotid artery; ; carotid body; ; left lung lobe; ; digastric muscle; ; lumbar subsegment of spinal cord; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; protein binding; phosphoprotein phosphatase activity; hydrolase activity;
Cellular component	integral component of membrane; receptor complex; integral component of plasma membrane; membrane; plasma membrane; specific granule membrane; tertiary granule membrane;
Biological process	phosphate-containing compound metabolic process; protein dephosphorylation; angiogenesis; dephosphorylation; peptidyl-tyrosine dephosphorylation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5787
	19263
	ENSG00000127329
	ENSMUSG00000020154
	P23467
	B2RU80
	NM_001109754; NM_001206971; NM_001206972; NM_002837; NM_001330204
	NM_029928
	NP_001103224; NP_001193900; NP_001193901; NP_001317133; NP_002828
	NP_084204
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the PTPRB gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127329 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020154 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PTPRB protein tyrosine phosphatase, receptor type, B".
^ Fachinger G, Deutsch U, Risau W (October 1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2". Oncogene. 18 (43): 5948–5953. doi:10.1038/sj.onc.1202992. PMID 10557082.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127329 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020154 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PTPRB protein tyrosine phosphatase, receptor type, B".

[Fachinger_1999-6] Fachinger G, Deutsch U, Risau W (October 1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2". Oncogene. 18 (43): 5948–5953. doi:10.1038/sj.onc.1202992. PMID 10557082.

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