 | This article may be too technical for most readers to understand. (July 2024) |
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene.[5] PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA).[6]
PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells, particularly lymphocytes. It plays a key role in the activation and differentiation of T cells, B cells, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for immune response and homeostasis.[7][8]
- ^ a b c ENSG00000262418 GRCh38: Ensembl release 89: ENSG00000081237, ENSG00000262418 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026395 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. (September 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proceedings of the National Academy of Sciences of the United States of America. 87 (18): 7000–7004. Bibcode:1990PNAS...87.7000K. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617.
- ^ "Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C".
- ^ Cite error: The named reference
pmid12414720was invoked but never defined (see the help page). - ^ Thomas ML (1989). "The leukocyte common antigen family". Annual Review of Immunology. 7: 339–69. doi:10.1146/annurev.iy.07.040189.002011. PMID 2523715.