PTPRM

PTPRM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RPM, 2C9A, 2V5Y
Identifiers
Aliases	PTPRM, PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu, protein tyrosine phosphatase, receptor type M, protein tyrosine phosphatase receptor type M
External IDs	OMIM: 176888; MGI: 102694; HomoloGene: 37694; GeneCards: PTPRM; OMA:PTPRM - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	8,406,861 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	67,661,452 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; visceral pleura; ; right lung; ; Achilles tendon; ; lateral nuclear group of thalamus; ; tibia; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; subcutaneous adipose tissue; ; ventricle;
	Top expressed in
	left lung lobe; ; right ventricle; ; right lung; ; cardiac muscle tissue of left ventricle; ; right lung lobe; ; cerebellar vermis; ; lobe of cerebellum; ; ventromedial nucleus; ; lateral geniculate nucleus; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; cadherin binding; protein binding; identical protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; cell-cell junction; integral component of plasma membrane; perinuclear region of cytoplasm; lamellipodium; plasma membrane;
Biological process	dephosphorylation; retina layer formation; protein dephosphorylation; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; cell adhesion; negative regulation of angiogenesis; neuron projection development; signal transduction; homophilic cell adhesion via plasma membrane adhesion molecules; retinal ganglion cell axon guidance; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5797
	19274
	ENSG00000173482
	ENSMUSG00000033278
	P28827
	P28828
NM_001105244; NM_002845; NM_001378142; NM_001378143; NM_001378144;
	NM_001378145; NM_001378146; NM_001378147
	NM_008984; NM_001357625
NP_001098714; NP_002836; NP_001365071; NP_001365072; NP_001365073;
	NP_001365074; NP_001365075; NP_001365076
	NP_033010; NP_001344554
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173482 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033278 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gebbink MF, van Etten I, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Geurts van Kessel A, Moolenaar WH (Nov 1991). "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase". FEBS Lett. 290 (1–2): 123–30. doi:10.1016/0014-5793(91)81241-Y. PMID 1655529. S2CID 7237197.
^ Suijkerbuijk RF, Gebbink MF, Moolenaar WH, Geurts van Kessel A (Nov 1993). "Fine mapping of the human receptor-like protein tyrosine phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 64 (3–4): 245–6. doi:10.1159/000133598. PMID 8404049.
^ "Entrez Gene: PTPRM protein tyrosine phosphatase, receptor type, M".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173482 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033278 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1655529-5] Gebbink MF, van Etten I, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Geurts van Kessel A, Moolenaar WH (Nov 1991). "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase". FEBS Lett. 290 (1–2): 123–30. doi:10.1016/0014-5793(91)81241-Y. PMID 1655529. S2CID 7237197.

[pmid8404049-6] Suijkerbuijk RF, Gebbink MF, Moolenaar WH, Geurts van Kessel A (Nov 1993). "Fine mapping of the human receptor-like protein tyrosine phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 64 (3–4): 245–6. doi:10.1159/000133598. PMID 8404049.

[entrez-7] "Entrez Gene: PTPRM protein tyrosine phosphatase, receptor type, M".

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