PTPRR

PTPRR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A8B
Identifiers
Aliases	PTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R
External IDs	OMIM: 602853; MGI: 109559; HomoloGene: 2135; GeneCards: PTPRR; OMA:PTPRR - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	70,920,738 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	116,110,837 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; right hemisphere of cerebellum; ; prefrontal cortex; ; entorhinal cortex; ; jejunal mucosa; ; mucosa of transverse colon; ; Brodmann area 46; ; testicle; ; orbitofrontal cortex; ; cerebellar vermis;
	Top expressed in
	Ileal epithelium; ; zygote; ; secondary oocyte; ; entorhinal cortex; ; perirhinal cortex; ; lobe of cerebellum; ; CA3 field; ; jejunum; ; transitional epithelium of urinary bladder; ; lumbar spinal ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; protein kinase binding; hydrolase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; cell junction; perinuclear region of cytoplasm; extracellular space; cytoplasm; cytosol;
Biological process	protein dephosphorylation; in utero embryonic development; ERBB2 signaling pathway; regulation of homophilic cell adhesion; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine dephosphorylation; negative regulation of epithelial cell migration; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5801
	19279
	ENSG00000153233
	ENSMUSG00000020151
	Q15256
	Q62132
	NM_001207015; NM_001207016; NM_002849; NM_130846
NM_001161837; NM_001161838; NM_001161839; NM_001161840; NM_011217;
	NM_001358484
	NP_001193944; NP_001193945; NP_002840; NP_570897
NP_001155309; NP_001155310; NP_001155311; NP_001155312; NP_035347;
	NP_001345413
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153233 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020151 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H (Nov 1995). "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase". Gene. 162 (2): 279–84. doi:10.1016/0378-1119(95)00306-Q. PMID 7557444.
^ van den Maagdenberg AM, Schepens JT, Schepens MT, Merkx GF, Darroudi F, Wieringa B, Geurts van Kessel A, Hendriks WJ (Jul 1999). "Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization". Cytogenet Cell Genet. 84 (3–4): 243–4. doi:10.1159/000015268. PMID 10393441. S2CID 35964382.
^ "Entrez Gene: PTPRR protein tyrosine phosphatase, receptor type, R".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153233 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020151 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7557444-5] Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H (Nov 1995). "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase". Gene. 162 (2): 279–84. doi:10.1016/0378-1119(95)00306-Q. PMID 7557444.

[pmid10393441-6] van den Maagdenberg AM, Schepens JT, Schepens MT, Merkx GF, Darroudi F, Wieringa B, Geurts van Kessel A, Hendriks WJ (Jul 1999). "Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization". Cytogenet Cell Genet. 84 (3–4): 243–4. doi:10.1159/000015268. PMID 10393441. S2CID 35964382.

[entrez-7] "Entrez Gene: PTPRR protein tyrosine phosphatase, receptor type, R".

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