Paeonol

Paeonol
Chemical structure of paeonol
Names
Preferred IUPAC name
1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one
Other names
2'-Hydroxy-4'-methoxyacetophenone
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.008.194 Edit this at Wikidata
UNII
  • InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
    Key: UILPJVPSNHJFIK-UHFFFAOYSA-N
  • InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
    Key: UILPJVPSNHJFIK-UHFFFAOYAG
  • CC(=O)C1=C(C=C(C=C1)OC)O
Properties
C9H10O3
Molar mass 166.176 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Paeonol is a phenolic compound found in peonies[2] such as Paeonia suffruticosa (moutan cortex),[3][4] in Arisaema erubescens,[5] and in Dioscorea japonica.[6] It is a chemical compound found in some traditional Chinese medicines.[7]

  1. ^ "CAS # 552-41-0, Paeonol, 2'-Hydroxy-4'-methoxyacetophenone, 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one".
  2. ^ Zhang, L., Li, D. C., & Liu, L. F. (2019). Paeonol: pharmacological effects and mechanisms of action. International immunopharmacology, 72, 413-421. PMID 31030097 doi:10.1016/j.intimp.2019.04.033
  3. ^ Fukuhara Y, Yoshida D (1987). "Paeonol: a bio-antimutagen isolated from a crude drug, moutan cortex". Agricultural and Biological Chemistry. 51 (5): 1441–1442. doi:10.1271/bbb1961.51.1441. INIST 7609719.
  4. ^ Wu, Xinan; Chen, Hongli; Chen, Xingguo; Hu, Zhide (2003). "Determination of paeonol in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies following oral administration of Moutan cortex decoction". Biomedical Chromatography. 17 (8): 504–8. doi:10.1002/bmc.259. PMID 14648606.
  5. ^ Ducki S, Hadfield JA, Lawrence NJ, Zhang X, McGown AT (1995). "Isolation of paeonol from Arisaema erubescens". Planta Medica. 61 (6): 586–587. doi:10.1055/s-2006-959390. PMID 8824957. INIST 2920867.
  6. ^ Miyazawa, Mitsuo; Shimamura, Hideo; Nakamura, Sei-Ichi; Kameoka, Hiromu (1996). "Antimutagenic Activity of (+)-β-Eudesmol and Paeonol fromDioscorea japonica". Journal of Agricultural and Food Chemistry. 44 (7): 1647–1650. doi:10.1021/jf950792u.
  7. ^ Deng, Chunhui; Yao, Ning; Wang, Ben; Zhang, Xiangmin (2006). "Development of microwave-assisted extraction followed by headspace single-drop microextraction for fast determination of paeonol in traditional Chinese medicines". Journal of Chromatography A. 1103 (1): 15–21. doi:10.1016/j.chroma.2005.11.023. PMID 16309693.