Paget's disease of the breast

Paget's disease of the breast
Other namesPaget disease of the breast, Paget's disease of the nipple, Mammary Paget's disease[1]
Paget's disease of the nipple
Pronunciation
SpecialtyOncology Edit this on Wikidata
Named afterJames Paget

Paget's disease of the breast (also known as mammary Paget's disease) is a rare skin change at the nipple nearly always associated with underlying breast cancer.[2] Paget's disease of the breast was first described by Sir James Paget in 1874.[3] The condition is an uncommon disease accounting for 1 to 4% of all breast cancers cases.[2] 92% to 100% of patients with Paget's disease of the breast have an underlying breast cancer.[4]

The condition in itself often appears innocuous, limited to a surface appearance and it is sometimes dismissed, although it is actually indicative of underlying breast cancer.[3][5]

  1. ^ Dalberg K, Hellborg H, Wärnberg F (September 2008). "Paget's disease of the nipple in a population based cohort". Breast Cancer Research and Treatment. 111 (2): 313–9. doi:10.1007/s10549-007-9783-5. PMID 17952590. S2CID 21650163.
  2. ^ a b "Paget Disease of the Breast - NCI". www.cancer.gov. 2012-05-21. Retrieved 2023-10-09.
  3. ^ a b Thin, George (1881). "On the Connection Between Disease of the Nipple and Areola and Tumours of the Breast". Trans Pathol Soc Lond. 32: 218.
  4. ^ Markarian, Sione (2022-05-14). "Mammary Paget's Disease: An Update". Cancers. 14 (10): 2422. doi:10.3390/cancers14102422. PMC 9139704. PMID 35626023.
  5. ^ Karakas, Cansu (2011). "Paget's disease of the breast". Journal of Carcinogenesis. 10: 31. doi:10.4103/1477-3163.90676. ISSN 1477-3163. PMC 3263015. PMID 22279416.