Pan-American, Pan American, Panamerican, Pan-America, Pan America or Panamerica may refer to:
- Collectively, the Americas: North America, Central America, South America and the Caribbean
- Something of, from, or related to the Americas
- Pan-Americanism, an integrationist movement among the nations of the Americas
- Pan American Union, later the Organization of American States
- Pan Am, a former international airline carrier based in the United States.
- Pan American Petroleum and Transport Company, a defunct oil company
- Pan-American (train), a L&N train that ran from Cincinnati to New Orleans
- SS Pan America, a steamship
- Pan American (band), an ambient/post-rock music ensemble
- "Pan American" (song), a 1947 song by Hank Williams