Pancuronium bromide

Pancuronium
Clinical data
AHFS/Drugs.com	Monograph
Pregnancy; category	AU: B2; ;
Routes of; administration	Intravenous
ATC code	M03AC01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	NA
Protein binding	77 to 91%
Metabolism	Hepatic
Elimination half-life	1.5 to 2.7 hours
Excretion	Renal and biliary
Identifiers
	IUPAC name [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-Acetyloxy-10,13-dimethyl-2,16-bis(pyridin-1-yl)-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;
CAS Number	16974-53-1 ; bromide: 15500-66-0 ;
PubChem CID	441289;
IUPHAR/BPS	4001;
DrugBank	DB01337 ;
ChemSpider	25453 ;
UNII	J76UF062FS; bromide: U9LY9Y75X2 ;
KEGG	D00492 ;
ChEBI	CHEBI:7908 ;
ChEMBL	ChEMBL185073 ;
CompTox Dashboard (EPA)	DTXSID9023415 ;
ECHA InfoCard	100.035.923
Chemical and physical data
Formula	C35H60N2O4
Molar mass	572.875 g·mol−1
	InChI InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1 ; Key:NPIJXCQZLFKBMV-YTGGZNJNSA-L ;
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Pancuronium (trademarked as Pavulon) is an aminosteroid muscle relaxant with various medical uses.^[1] It is used in euthanasia and is used in some states as the second of three drugs administered during lethal injections in the United States.

^ Das GN, Sharma P, Maani CV (January 2021). "Pancuronium". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30855929.

[pmid30855929-1] Das GN, Sharma P, Maani CV (January 2021). "Pancuronium". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30855929.

[1]

Clinical data


AHFS/Drugs.com	Monograph
Pregnancy category	AU: B2
Routes of administration	Intravenous
ATC code	M03AC01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	NA
Protein binding	77 to 91%
Metabolism	Hepatic
Elimination half-life	1.5 to 2.7 hours
Excretion	Renal and biliary
Identifiers
IUPAC name [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-Acetyloxy-10,13-dimethyl-2,16-bis(pyridin-1-yl)-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
CAS Number	16974-53-1^Y bromide: 15500-66-0^Y
PubChem CID	441289
IUPHAR/BPS	4001
DrugBank	DB01337^Y
ChemSpider	25453^N
UNII	J76UF062FS bromide: U9LY9Y75X2^Y
KEGG	D00492^Y
ChEBI	CHEBI:7908^N
ChEMBL	ChEMBL185073^N
CompTox Dashboard (EPA)	DTXSID9023415
ECHA InfoCard	100.035.923
Chemical and physical data
Formula	C₃₅H₆₀N₂O₄
Molar mass	572.875 g·mol⁻¹
InChI InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1^N Key:NPIJXCQZLFKBMV-YTGGZNJNSA-L^N
^NY (what is this?) (verify)