Clinical data | |
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Trade names | Protonix, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601246 |
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Routes of administration | By mouth and intravenous |
Drug class | Proton-pump inhibitor |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | 77% |
Protein binding | 98% |
Metabolism | Liver (CYP2C19, CYP3A4) |
Elimination half-life | 1-2 hours |
Excretion | Urine, feces |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.111.005 |
Chemical and physical data | |
Formula | C16H15F2N3O4S |
Molar mass | 383.37 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic |
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Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.[5][6] It may also be used along with other medications to eliminate Helicobacter pylori.[7] Pantoprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs.[8] It is available by mouth and by injection into a vein.[5]
Common side effects include headaches, diarrhea, abdominal pain, and joint pain.[5][6] More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridioides difficile colitis, low magnesium, and vitamin B12 deficiency.[5] Use in pregnancy appears to be safe.[5] Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion.[5] It works by inactivating (H+/K+)-ATPase function in the stomach.[9][5]
The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994.[10] It is available as a generic medication.[5][11] In 2022, it was the sixteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions.[12][13] In Australia, it was one of the top 10 most prescribed medications between 2017 and 2023.[14]
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