Parathyroid carcinoma

Parathyroid carcinoma
Parathyroid gland anatomy(green marks)
SpecialtyOncology, ENT surgery

Parathyroid carcinoma is a rare cancer resulting in parathyroid adenoma to carcinoma progression.[1] It forms in tissues of one or more of the parathyroid glands (four pea-sized glands in the neck that make parathyroid hormone (PTH). PTH helps the body maintain normal levels of serum calcium by promoting calcium reabsorption from bone. It is antagonized by the hormone calcitonin, which prompts calcium storage.).

It is rare, with documented cases of less than one thousand since its first discovery in 1904;[2][3][4][5][6][7] and much less common than parathyroid adenoma. It can be difficult to excise.[8] The rate of occurrence of parathyroid carcinoma is between 0.5% to 5%[9][10][6][11]

  1. ^ Hu MI, Vassilopoulou-Sellin R, Lustig R, Lamont JP. "Thyroid and Parathyroid Cancers" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
  2. ^ Givi B, Shah JP (August 2010). "Parathyroid carcinoma". Clinical Oncology. 22 (6): 498–507. doi:10.1016/j.clon.2010.04.007. PMC 3781923. PMID 20510594.
  3. ^ Wei CH, Harari A (March 2012). "Parathyroid carcinoma: update and guidelines for management". Current Treatment Options in Oncology. 13 (1): 11–23. doi:10.1007/s11864-011-0171-3. PMID 22327883. S2CID 39872789.
  4. ^ Dudney WC, Bodenner D, Stack BC (April 2010). "Parathyroid carcinoma". Otolaryngologic Clinics of North America. Thyroid and Parathyroid Surgery. 43 (2): 441–53, xi. doi:10.1016/j.otc.2010.01.011. PMID 20510726.
  5. ^ Beus KS, Stack BC (August 2004). "Parathyroid carcinoma". Otolaryngologic Clinics of North America. Parathyroids. 37 (4): 845–54, x. doi:10.1016/j.otc.2004.02.014. PMID 15262520.
  6. ^ a b Healy SJ, Soe KK (2016-06-01). "Parathyroid Cancer Cases: A Single Center's Experience". AACE Clinical Case Reports. 2 (3): e221–e227. doi:10.4158/EP15857.CR. ISSN 2376-0605.
  7. ^ Lee JE (July 2005). "Predicting the presence of parathyroid carcinoma". Annals of Surgical Oncology. 12 (7): 513–514. doi:10.1245/ASO.2005.03.904. PMID 15952075. S2CID 195245925.
  8. ^ "Endocrine Pathology". Retrieved 2009-05-08.
  9. ^ Wynne AG, van Heerden J, Carney JA, Fitzpatrick LA (July 1992). "Parathyroid carcinoma: clinical and pathologic features in 43 patients". Medicine. 71 (4): 197–205. doi:10.1097/00005792-199207000-00002. PMID 1518393. S2CID 25457018.
  10. ^ Mohebati A, Shaha A, Shah J (December 2012). "Parathyroid carcinoma: challenges in diagnosis and treatment". Hematology/Oncology Clinics of North America. Rare Cancers. 26 (6): 1221–1238. doi:10.1016/j.hoc.2012.08.009. PMID 23116578.
  11. ^ Givi B, Shah JP (August 2010). "Parathyroid carcinoma". Clinical Oncology. 22 (6): 498–507. doi:10.1016/j.clon.2010.04.007. PMC 3781923. PMID 20510594.