Parathyroid hormone receptor

parathyroid hormone 2 receptor
parathyroid hormone 2 receptor
Identifiers
Symbol	PTH2R
NCBI gene	5746
HGNC	9609
OMIM	601469
RefSeq	NM_005048
UniProt	P49190
Other data
Locus	Chr. 2 q33
Structures
Search for
Structures	Swiss-model
Domains	InterPro

parathyroid hormone 1 receptor
parathyroid hormone 1 receptor
Identifiers
Symbol	PTH1R
Alt. symbols	PTHR, PFE
NCBI gene	5745
HGNC	9608
OMIM	168468
RefSeq	NM_000316
UniProt	Q03431
Other data
Locus	Chr. 3 p22-p21.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.^[1]

parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.^[2]^[3]
parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.^[4]

^ Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140.
^ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. doi:10.1152/ajprenal.1999.277.5.F665. PMID 10564229. Archived from the original on 2009-02-13. Retrieved 2007-11-01.
^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/mend.10.5.8732687. PMID 8732687.
^ Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels. 8 (3–4): 211–8. doi:10.1080/10606820213682. PMID 12529938.