| Patau syndrome | |
|---|---|
| Other names | Trisomy 13, trisomy D, T13[1] |
 | |
| Infant with Patau syndrome showing cleft lip, reduction of nose, and hypotelorism (c. 1912) | |
| Pronunciation | |
| Specialty | Medical genetics |
| Usual onset | Present at birth |
| Causes | Third copy of chromosome 13 |
| Treatment | Supportive care |
| Prognosis | Poor |
| Named after | Klaus Patau |
Patau syndrome is a syndrome caused by a chromosomal abnormality, in which some or all of the cells of the body contain extra genetic material from chromosome 13. The extra genetic material disrupts normal development, causing multiple and complex organ defects.
This can occur either because each cell contains a full extra copy of chromosome 13 (a disorder known as trisomy 13 or trisomy D or T13[1]), or because each cell contains an extra partial copy of the chromosome, or because there are two different lines of cells—one healthy with the correct number of chromosomes 13 and one that contains an extra copy of the chromosome—mosaic Patau syndrome. Full trisomy 13 is caused by nondisjunction of chromosomes during meiosis; the mosaic form is caused by nondisjunction during mitosis.
Like all nondisjunction conditions (such as Down syndrome and Edwards syndrome), the risk of this syndrome in the offspring increases with maternal age at pregnancy, with about 31 years being the average.[2] Patau syndrome affects somewhere between 1 in 10,000 and 1 in 21,700 live births.[3]
- ^ a b "Trisomy 13: description in brief". GOV.UK. December 2020.
- ^ "Prevalence and Incidence of Patau syndrome". Diseases Center-Patau Syndrome. Adviware Pty Ltd. 2008-02-04. Retrieved 2008-02-17.
mean maternal age for this abnormality is about 31 years
- ^ About.com > Patau Syndrome (Trisomy 13) Archived 2016-03-04 at the Wayback Machine From Krissi Danielsson. Updated June 10, 2009