Patrick O'Connor may refer to:
- Patrick O'Connor (sprinter) (born 1966), Jamaican sprinter
- Patrick O'Connor (hurler) (born 1991), Irish hurler
- Patrick O'Connor (Australian politician) (1862–1923)
- Patrick O'Connor (Manitoba politician)
- Patrick O'Connor (bishop) (1848–1932), Irish-born Roman Catholic bishop of Armidale, New South Wales, Australia
- Patrick O'Connor (Massachusetts politician) (born 1984), American politician
- Patrick O'Connor (American football) (born 1993), American football defensive end
- Patrick O'Connor (painter) (1909–1997), American painter
- Patrick J. O'Connor (born 1955), Chicago city alderman
- Patrick John O'Connor (1924–1990), New Zealand wrestler
- Patrick O'Connor (judge) (1914–2001), British judge
- Patrick Edward O'Connor, Roman Catholic priest
- Patrick O'Connor, Irish immigrant hanged in Iowa, see Hanging of Patrick O'Connor
- Padraic Fiacc (Patrick Joseph O'Connor, 1924–2019), Irish poet
- Paddy O'Connor (1879–1950), baseball player
- pseudonym of the writer Leonard Wibberley (1915–1983)
- Patrick O'Connor, Australian actor known for playing Dean Thompson in Home and Away