Paxillin

PXN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2O9V, 2VZD, 2VZG, 2VZI, 3GM1, 3PY7, 3U3F, 4EDN, 1OW6, 1OW7, 1OW8, 3RQE, 3RQF, 3RQG, 4XGZ, 4XH2
Identifiers
Aliases	PXN, entrez:5829, paxillin
External IDs	OMIM: 602505; MGI: 108295; HomoloGene: 37697; GeneCards: PXN; OMA:PXN - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 120,210,439 bp[1] End 120,265,771 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 56.1 cM Start 115,644,735 bp[2] End 115,694,046 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte tibial nerve left uterine tube apex of heart gastrocnemius muscle canal of the cervix muscle layer of sigmoid colon upper lobe of left lung body of uterus transverse colon Top expressed in granulocyte vestibular membrane of cochlear duct internal carotid artery external carotid artery endothelial cell of lymphatic vessel retinal pigment epithelium right lung lobe left lung tibiofemoral joint stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function beta-catenin binding vinculin binding protein-containing complex binding metal ion binding integrin binding protein binding protein kinase binding ubiquitin protein ligase binding neuropilin binding protein phosphatase binding transcription coregulator activity Cellular component focal adhesion plasma membrane stress fiber microtubule associated complex cell junction cell cortex cytoskeleton lamellipodium cytoplasm cytosol adherens junction Biological process muscle contraction epidermal growth factor receptor signaling pathway signal complex assembly cellular response to reactive oxygen species vascular endothelial growth factor receptor signaling pathway cell adhesion growth hormone receptor signaling pathway cell-matrix adhesion transforming growth factor beta receptor signaling pathway signal transduction response to peptide endothelial cell migration positive regulation of stress fiber assembly substrate adhesion-dependent cell spreading regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5829 19303 Ensembl ENSG00000089159 ENSMUSG00000029528 UniProt P49023 Q8VI36 RefSeq (mRNA) NM_001080855 NM_001243756 NM_002859 NM_025157 NM_001385981 NM_001385982 NM_001385983 NM_001385984 NM_001385985 NM_001385986 NM_001385987 NM_001385988 NM_001385989 NM_001385990 NM_011223 NM_133915 RefSeq (protein) NP_001074324 NP_001230685 NP_002850 NP_079433 NP_035353 NP_598676 NP_001389995 NP_001389996 NP_001389997 NP_001389998 NP_001389999 Location (UCSC) Chr 12: 120.21 – 120.27 Mb Chr 5: 115.64 – 115.69 Mb PubMed search [3] [4]
Wikidata
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Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Mutations in PXN as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers.